Sitagliptin for prevention of stress hyperglycemia in patients without diabetes undergoing general surgery: A pilot randomized study.
J Diabetes Complications
; 32(12): 1091-1096, 2018 Dec.
Article
em En
| MEDLINE
| ID: mdl-30253968
ABSTRACT
AIM:
We investigated if a dipeptidyl peptidase-4 inhibitor, sitagliptin, can prevent perioperative stress hyperglycemia in patients without prior history of diabetes mellitus undergoing general surgery.METHODS:
This double-blind pilot trial randomized general surgery patients to receive sitagliptin (nâ¯=â¯44) or placebo (nâ¯=â¯36) once daily, starting one day prior to surgery and continued during the hospital stay. The primary outcome was occurrence of stress hyperglycemia, defined by blood glucose (BG) >140â¯mg/dL and >180â¯mg/dL after surgery. Secondary outcomes included length-of-stay, ICU transfers, hypoglycemia, and hospital complications.RESULTS:
BG >140 mg/dL was present in 44 (55%) of subjects following surgery. There were no differences in hyperglycemia between placebo and sitagliptin (56% vs. 55%, pâ¯=â¯0.93). BG >180 mg/dL was observed in 19% and 11% of patients treated with placebo and sitagliptin, respectively, pâ¯=â¯0.36. Both treatment groups had resulted in similar postoperative BG (148.9⯱â¯29.4â¯mg/dL vs. 146.9⯱â¯35.2â¯mg/dL, pâ¯=â¯0.73). There were no differences in length-of-stay (4 vs. 3â¯days, pâ¯=â¯0.84), ICU transfer (3% vs. 5%, pâ¯=â¯1.00), hypoglycemia <70â¯mg/dL (6% vs. 11%, pâ¯=â¯0.45), and complications (14% vs. 18%, pâ¯=â¯0.76).CONCLUSION:
Preoperative treatment with sitagliptin did not prevent stress hyperglycemia or complications in individuals without diabetes undergoing surgery.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Psicológico
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Procedimentos Cirúrgicos Operatórios
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Cuidados Pré-Operatórios
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Fosfato de Sitagliptina
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Hiperglicemia
Tipo de estudo:
Clinical_trials
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Etiology_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article