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Elevated brain oxygen extraction fraction in preterm newborns with anemia measured using noninvasive MRI.
Morris, Emily A; Juttukonda, Meher R; Lee, Chelsea A; Patel, Niral J; Pruthi, Sumit; Donahue, Manus J; Jordan, Lori C.
Afiliação
  • Morris EA; Department of Pediatrics, Division of Neonatology, Vanderbilt University Medical Center, Nashville, TN, USA. emily.a.morris@vumc.org.
  • Juttukonda MR; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Lee CA; Department of Pediatrics, Division of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Patel NJ; Department of Pediatrics, Division of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Pruthi S; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Donahue MJ; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Jordan LC; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
J Perinatol ; 38(12): 1636-1643, 2018 12.
Article em En | MEDLINE | ID: mdl-30254332
OBJECTIVE: To test the hypothesis that cerebral oxygen extraction fraction (OEF) is elevated and inversely related to hematocrit level in anemic former very-low-birth-weight infants near term. STUDY DESIGN: Prospective study of non-sedated preterm infants (post-menstrual age = 36 ± 2 weeks) over a range of hematocrits (0.23-0.49). Anatomical (T1-W, T2-W, and diffusion-weighted), cerebral blood flow (CBF), and OEF 3-T MRI were utilized. Statistical analysis included Spearman's rank-order correlation testing between study variables and intraclass correlation coefficients (ICC) calculated between consecutively acquired OEF scans. RESULTS: Consecutive OEF measurements showed moderate-to-good agreement (ICC = 0.71; 95% CI = 0.40-0.87). OEF increased with worsening anemia (ρ = -0.58; p = 0.005), and OEF and basal ganglia CBF were positively correlated (ρ = 0.49; p = 0.023). CONCLUSION: Noninvasive OEF MRI has moderate-to-good repeatability in non-sedated former preterm infants nearing term-equivalent age. Strong correlation of elevated OEF with anemia suggests hemodynamic compensation for anemia and could establish OEF as a useful biomarker of transfusion threshold for preterm infants.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxigênio / Encéfalo / Anemia Tipo de estudo: Observational_studies Limite: Female / Humans / Infant / Male / Newborn Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxigênio / Encéfalo / Anemia Tipo de estudo: Observational_studies Limite: Female / Humans / Infant / Male / Newborn Idioma: En Ano de publicação: 2018 Tipo de documento: Article