Extrasynaptic &#945;<sub>5</sub>GABA<sub>A</sub> receptors on proprioceptive afferents produce a tonic depolarization that modulates sodium channel function in the rat spinal cord.

Lucas-Osma, Ana M; Li, Yaqing; Lin, Shihao; Black, Sophie; Singla, Rahul; Fouad, Karim; Fenrich, Keith K; Bennett, David J

Extrasynaptic α₅GABA_A receptors on proprioceptive afferents produce a tonic depolarization that modulates sodium channel function in the rat spinal cord.

Lucas-Osma, Ana M; Li, Yaqing; Lin, Shihao; Black, Sophie; Singla, Rahul; Fouad, Karim; Fenrich, Keith K; Bennett, David J.

Afiliação

Lucas-Osma AM; Neuroscience and Mental Health Institute and Faculty of Rehabilitation Medicine, University of Alberta , Edmonton, AB , Canada.
Li Y; Neuroscience and Mental Health Institute and Faculty of Rehabilitation Medicine, University of Alberta , Edmonton, AB , Canada.
Lin S; Neuroscience and Mental Health Institute and Faculty of Rehabilitation Medicine, University of Alberta , Edmonton, AB , Canada.
Black S; Neuroscience and Mental Health Institute and Faculty of Rehabilitation Medicine, University of Alberta , Edmonton, AB , Canada.
Singla R; Neuroscience and Mental Health Institute and Faculty of Rehabilitation Medicine, University of Alberta , Edmonton, AB , Canada.
Fouad K; Neuroscience and Mental Health Institute and Faculty of Rehabilitation Medicine, University of Alberta , Edmonton, AB , Canada.
Fenrich KK; Neuroscience and Mental Health Institute and Faculty of Rehabilitation Medicine, University of Alberta , Edmonton, AB , Canada.
Bennett DJ; Neuroscience and Mental Health Institute and Faculty of Rehabilitation Medicine, University of Alberta , Edmonton, AB , Canada.

J Neurophysiol ; 120(6): 2953-2974, 2018 12 01.

Article em En | MEDLINE | ID: mdl-30256739

Assuntos

Potenciais da Membrana; Neurônios Aferentes/metabolismo; Propriocepção; Receptores de GABA-A/metabolismo; Canais de Sódio/metabolismo; Medula Espinal/metabolismo; Animais; Feminino; Antagonistas de Receptores de GABA-A/farmacologia; Inibição Neural; Neurônios Aferentes/efeitos dos fármacos; Neurônios Aferentes/fisiologia; Ratos; Ratos Sprague-Dawley; Medula Espinal/citologia; Medula Espinal/fisiologia; Sinapses/metabolismo; Sinapses/fisiologia

Palavras-chave

GABA; antidromic action potential; branch point failure; dorsal root; dorsal root reflex; extrasynaptic; intracellular recording; primary afferent depolarization; spinal cord

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Propriocepção / Medula Espinal / Canais de Sódio / Receptores de GABA-A / Potenciais da Membrana / Neurônios Aferentes Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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