Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase.

Muñoz, Ivan M; Morgan, Michael E; Peltier, Julien; Weiland, Florian; Gregorczyk, Mateusz; Brown, Fiona Cm; Macartney, Thomas; Toth, Rachel; Trost, Matthias; Rouse, John

Muñoz, Ivan M; Morgan, Michael E; Peltier, Julien; Weiland, Florian; Gregorczyk, Mateusz; Brown, Fiona Cm; Macartney, Thomas; Toth, Rachel; Trost, Matthias; Rouse, John.

Afiliação

Muñoz IM; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Morgan ME; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Peltier J; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Weiland F; Faculty of Medical Sciences, Institute for Cell and Molecular Biosciences, Newcastle upon Tyne, UK.
Gregorczyk M; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Brown FC; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Macartney T; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Toth R; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Trost M; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Rouse J; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK matthias.trost@ncl.ac.uk j.rouse@dundee.ac.uk.

EMBO J ; 37(24)2018 12 14.

Article em En | MEDLINE | ID: mdl-30266825

Assuntos

Síndromes Epilépticas/metabolismo; Proteínas de Membrana/metabolismo; Proteínas Associadas aos Microtúbulos/metabolismo; Proteínas Serina-Treonina Quinases/metabolismo; Espasmos Infantis/metabolismo; Proteínas Supressoras de Tumor/metabolismo; Motivos de Aminoácidos; Proteínas de Ciclo Celular/genética; Linhagem Celular Tumoral; Centrossomo/metabolismo; Proteínas do Citoesqueleto; Síndromes Epilépticas/genética; Síndromes Epilépticas/patologia; Células HEK293; Humanos; Proteínas de Membrana/genética; Proteínas dos Microtúbulos/genética; Proteínas Associadas aos Microtúbulos/genética; Microtúbulos/genética; Microtúbulos/metabolismo; Mutação; Proteínas Serina-Treonina Quinases/genética; Proteômica; Espasmos Infantis/genética; Espasmos Infantis/patologia; Proteínas Supressoras de Tumor/genética

Palavras-chave

CDKL5 disorder; centrosome; cilia; kinase; microtubule

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espasmos Infantis / Proteínas Serina-Treonina Quinases / Proteínas Supressoras de Tumor / Síndromes Epilépticas / Proteínas de Membrana / Proteínas Associadas aos Microtúbulos Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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