Combination Therapy With Infliximab and Azathioprine Improves Infliximab Pharmacokinetic Features and Efficacy: A Post Hoc Analysis.

Colombel, Jean-Frédéric; Adedokun, Omoniyi J; Gasink, Christopher; Gao, Long-Long; Cornillie, Freddy J; D'Haens, Geert R; Rutgeerts, Paul J; Reinisch, Walter; Sandborn, William J; Hanauer, Stephen B

Colombel, Jean-Frédéric; Adedokun, Omoniyi J; Gasink, Christopher; Gao, Long-Long; Cornillie, Freddy J; D'Haens, Geert R; Rutgeerts, Paul J; Reinisch, Walter; Sandborn, William J; Hanauer, Stephen B.

Afiliação

Colombel JF; Department of Gastroenterology, Icahn School of Medicine, Mount Sinai Medical Center, New York, New York. Electronic address: jean-frederic.colombel@mssm.edu.
Adedokun OJ; Janssen Research & Development, Spring House, Pennsylvania.
Gasink C; Janssen Scientific Affairs, Horsham, Pennsylvania.
Gao LL; Janssen Scientific Affairs, Horsham, Pennsylvania.
Cornillie FJ; MSD International, Kriens, Switzerland.
D'Haens GR; Department of Gastroenterology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.
Rutgeerts PJ; Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium.
Reinisch W; Universitätsklinik für Innere Medizin III, Vienna, Austria.
Sandborn WJ; Division of Gastroenterology and Department of Medicine, University of California, San Diego, San Diego, California.
Hanauer SB; Department of Medicine, Digestive Health Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.

Clin Gastroenterol Hepatol ; 17(8): 1525-1532.e1, 2019 07.

Article em En | MEDLINE | ID: mdl-30267864

Assuntos

Azatioprina/farmacocinética; Doença de Crohn/tratamento farmacológico; Infliximab/farmacocinética; Indução de Remissão/métodos; Adulto; Doença de Crohn/sangue; Quimioterapia Combinada; Feminino; Fármacos Gastrointestinais/farmacocinética; Humanos; Imunossupressores/farmacocinética; Masculino; Pessoa de Meia-Idade; Resultado do Tratamento

Palavras-chave

Corticosteroid-Free Clinical Remission; Exposure-Response; Mucosal Healing; SONIC; Serum Infliximab Concentrations

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Azatioprina / Indução de Remissão / Doença de Crohn / Infliximab Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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