Intrauterine Programming of Glucocorticoid-Insulin-Like Growth Factor-1 Axis-Mediated Developmental Origin of Osteoporosis Susceptibility in Female Offspring Rats with Prenatal Caffeine Exposure.

Shangguan, Yangfan; Wen, Yinxian; Tan, Yang; Qin, Jun; Jiang, Hongqiang; Magdalou, Jacques; Chen, Liaobin; Wang, Hui

Shangguan, Yangfan; Wen, Yinxian; Tan, Yang; Qin, Jun; Jiang, Hongqiang; Magdalou, Jacques; Chen, Liaobin; Wang, Hui.

Afiliação

Shangguan Y; Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, People's Republic of China.
Wen Y; Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, People's Republic of China.
Tan Y; Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, People's Republic of China.
Qin J; Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, People's Republic of China.
Jiang H; Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, People's Republic of China.
Magdalou J; UMR 7561 CNRS-Université de Lorraine, Faculté de Médicine, Vandoeuvre-lès-Nancy, France.
Chen L; Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, People's Republic of China. Electronic address: lbchen@whu.edu.cn.
Wang H; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, People's Republic of China; Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, People's Republic of China. Electronic address: wanghui19@whu.edu.cn.

Am J Pathol ; 188(12): 2863-2876, 2018 12.

Article em En | MEDLINE | ID: mdl-30273601

Assuntos

Cafeína/toxicidade; Reprogramação Celular/efeitos dos fármacos; Retardo do Crescimento Fetal/patologia; Fator de Crescimento Insulin-Like I/metabolismo; Osteoporose/patologia; Efeitos Tardios da Exposição Pré-Natal/patologia; Animais; Animais Recém-Nascidos; Células Cultivadas; Estimulantes do Sistema Nervoso Central/toxicidade; Feminino; Retardo do Crescimento Fetal/induzido quimicamente; Retardo do Crescimento Fetal/metabolismo; Glucocorticoides/efeitos adversos; Osteogênese; Osteoporose/induzido quimicamente; Osteoporose/metabolismo; Gravidez; Efeitos Tardios da Exposição Pré-Natal/induzido quimicamente; Efeitos Tardios da Exposição Pré-Natal/metabolismo; Ratos; Ratos Wistar

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoporose / Efeitos Tardios da Exposição Pré-Natal / Cafeína / Fator de Crescimento Insulin-Like I / Reprogramação Celular / Retardo do Crescimento Fetal Tipo de estudo: Risk_factors_studies Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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