The S-layer protein of a <i>Clostridium difficile</i> SLCT-11 strain displays a complex glycan required for normal cell growth and morphology.

Richards, Emma; Bouché, Laura; Panico, Maria; Arbeloa, Ana; Vinogradov, Evgeny; Morris, Howard; Wren, Brendan; Logan, Susan M; Dell, Anne; Fairweather, Neil F

The S-layer protein of a Clostridium difficile SLCT-11 strain displays a complex glycan required for normal cell growth and morphology.

Richards, Emma; Bouché, Laura; Panico, Maria; Arbeloa, Ana; Vinogradov, Evgeny; Morris, Howard; Wren, Brendan; Logan, Susan M; Dell, Anne; Fairweather, Neil F.

Afiliação

Richards E; From the Department of Life Sciences, Imperial College London, SW7 2AZ London, United Kingdom.
Bouché L; From the Department of Life Sciences, Imperial College London, SW7 2AZ London, United Kingdom.
Panico M; From the Department of Life Sciences, Imperial College London, SW7 2AZ London, United Kingdom.
Arbeloa A; From the Department of Life Sciences, Imperial College London, SW7 2AZ London, United Kingdom.
Vinogradov E; the Vaccine Program, Human Health Therapeutics Research Centre, National Research Council, Ottawa, Ontario K1A 0R6, Canada.
Morris H; From the Department of Life Sciences, Imperial College London, SW7 2AZ London, United Kingdom,; Biopharmaspec, Suite 3.1, Lido Medical Centre, St. Saviours Road, JE2 7LA Jersey, United Kingdom, and.
Wren B; the London School of Hygiene and Tropical Medicine, WC1E 7HT, London, United Kingdom.
Logan SM; the Vaccine Program, Human Health Therapeutics Research Centre, National Research Council, Ottawa, Ontario K1A 0R6, Canada.
Dell A; From the Department of Life Sciences, Imperial College London, SW7 2AZ London, United Kingdom,. Electronic address: a.dell@imperial.ac.uk.
Fairweather NF; From the Department of Life Sciences, Imperial College London, SW7 2AZ London, United Kingdom,. Electronic address: n.fairweather@imperial.ac.uk.

J Biol Chem ; 293(47): 18123-18137, 2018 11 23.

Article em En | MEDLINE | ID: mdl-30275012

Assuntos

Clostridioides difficile/metabolismo; Glicoproteínas de Membrana/metabolismo; Polissacarídeos/metabolismo; Esporos Bacterianos/crescimento & desenvolvimento; Clostridioides difficile/genética; Clostridioides difficile/crescimento & desenvolvimento; Glicosilação; Espectrometria de Massas; Glicoproteínas de Membrana/química; Glicoproteínas de Membrana/genética; Peso Molecular; Polissacarídeos/química; Conformação Proteica; Esporos Bacterianos/genética; Esporos Bacterianos/metabolismo

Palavras-chave

Clostridium difficile; cell wall; genetics; glycomics; glycoprotein structure; glycoproteomics; glycosylation; mass spectrometry (MS); microbiology; nuclear magnetic resonance (NMR); surface layer; virulence

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polissacarídeos / Esporos Bacterianos / Glicoproteínas de Membrana / Clostridioides difficile Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google