[Relationship of Blimp-1 Hypoexpression with Pathogenesis of Aplastic Anemia].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
; 26(5): 1447-1452, 2018 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-30295266
ABSTRACT
OBJECTIVE:
To study the relationship of Blimp-1 hypoexpression with abnormality of Treg level and pathogenesis of aplastic anemia (AA).METHODS:
The mouse model with AA was established by adminis tration of IFN-γ combined with busulfan. The samples were collected at different day establishing AA model, and the spleen Treg number was detected, the Treg cells were sorted and expression level of prdm-1 was detected.RESULTS:
The number of Tregs in mice with AA was lower than that in control mice, moreover, the level of Treg decrease positively correlated with the AA severity (r=0.805), the higher the expression level of prdm-1, the higher the ratio of Treg/lymphocytes, showing positive correlation between them (r=0.548).CONCLUSION:
Blimp-1 expression may promote the proliferation and differentiation of Treg. The hypoexpression of Blimp-1 mediates the pathogenesis of AA and promotes progression of AA through reducing the proliferation of Treg, and decreacing the number of Treg.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T Reguladores
/
Anemia Aplástica
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2018
Tipo de documento:
Article