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Treatment of a metabolic liver disease by in vivo genome base editing in adult mice.
Villiger, Lukas; Grisch-Chan, Hiu Man; Lindsay, Helen; Ringnalda, Femke; Pogliano, Chiara B; Allegri, Gabriella; Fingerhut, Ralph; Häberle, Johannes; Matos, Joao; Robinson, Mark D; Thöny, Beat; Schwank, Gerald.
Afiliação
  • Villiger L; Department Biology, Institute for Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.
  • Grisch-Chan HM; Division of Metabolism, University Children's Hospital Zurich and Children's Research Centre, Zurich, Switzerland.
  • Lindsay H; SIB Swiss Institute of Bioinformatics, University of Zurich, Zurich, Switzerland.
  • Ringnalda F; Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
  • Pogliano CB; Department Biology, Institute for Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.
  • Allegri G; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland.
  • Fingerhut R; Division of Metabolism, University Children's Hospital Zurich and Children's Research Centre, Zurich, Switzerland.
  • Häberle J; Division of Metabolism, University Children's Hospital Zurich and Children's Research Centre, Zurich, Switzerland.
  • Matos J; Swiss Newborn Screening Laboratory, University Children's Hospital, Zurich, Switzerland.
  • Robinson MD; Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
  • Thöny B; Zurich Center for Integrative Human Physiology, Zurich, Switzerland.
  • Schwank G; Neuroscience Center Zurich, Zurich, Switzerland.
Nat Med ; 24(10): 1519-1525, 2018 10.
Article em En | MEDLINE | ID: mdl-30297904
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenilalanina Hidroxilase / Fenilcetonúrias / Sistemas CRISPR-Cas / Hepatopatias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenilalanina Hidroxilase / Fenilcetonúrias / Sistemas CRISPR-Cas / Hepatopatias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article