Pluripotent Stem Cell-Derived Pancreatic Progenitors and ß-Like Cells for Type 1 Diabetes Treatment.
Physiology (Bethesda)
; 33(6): 394-402, 2018 11 01.
Article
em En
| MEDLINE
| ID: mdl-30303772
ABSTRACT
In this review, we focus on the processes guiding human pancreas development and provide an update on methods to efficiently generate pancreatic progenitors (PPs) and ß-like cells in vitro from human pluripotent stem cells (hPSCs). Furthermore, we assess the strengths and weaknesses of using PPs and ß-like cell for cell replacement therapy for the treatment of Type 1 diabetes with respect to cell manufacturing, engrafting, functionality, and safety. Finally, we discuss the identification and use of specific cell surface markers to generate safer populations of PPs for clinical translation and to study the development of PPs in vivo and in vitro.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pâncreas
/
Células-Tronco Pluripotentes
/
Diabetes Mellitus Tipo 1
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Células Secretoras de Insulina
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article