Exploring the effect of N308D mutation on protein tyrosine phosphatase-2 cause gain-of-function activity by a molecular dynamics study.

Sun, Ying-Zhan; Chen, Xiu-Bo; Wang, Rui-Rui; Li, Wei-Ya; Ma, Ying

Sun, Ying-Zhan; Chen, Xiu-Bo; Wang, Rui-Rui; Li, Wei-Ya; Ma, Ying.

Afiliação

Sun YZ; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, China.
Chen XB; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, China.
Wang RR; Eye Hospital, Tianjin Medical University, School of Optometry and Ophthalmology, Tianjin Medical University, Tianjin, China.
Li WY; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, China.
Ma Y; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, China.

J Cell Biochem ; 120(4): 5949-5961, 2019 04.

Article em En | MEDLINE | ID: mdl-30304563

Assuntos

Simulação de Dinâmica Molecular; Proteína Fosfatase 2/química; Proteína Fosfatase 2/metabolismo; Domínio Catalítico/genética; Mutação com Ganho de Função/genética; Mutação/genética; Conformação Proteica; Proteína Fosfatase 2/genética; Estabilidade Proteica; Estrutura Secundária de Proteína

Palavras-chave

N308D mutation; Noonan syndrome; molecular dynamics; postdynamics analyses; protein tyrosine phosphatase-2

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Fosfatase 2 / Simulação de Dinâmica Molecular Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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