The folding equilibrium of huntingtin exon 1 monomer depends on its polyglutamine tract.

Bravo-Arredondo, Jose M; Kegulian, Natalie C; Schmidt, Thomas; Pandey, Nitin K; Situ, Alan J; Ulmer, Tobias S; Langen, Ralf

Bravo-Arredondo, Jose M; Kegulian, Natalie C; Schmidt, Thomas; Pandey, Nitin K; Situ, Alan J; Ulmer, Tobias S; Langen, Ralf.

Afiliação

Bravo-Arredondo JM; From the Departments of Physiology and Neuroscience and.
Kegulian NC; the Facultad de Ciencias Básicas, Ingeniería y Tecnología, Universidad Autónoma de Tlaxcala, Calzada Apizaquito S/N, 90300 Apizaco, Tlaxcala, Mexico.
Schmidt T; Biochemistry and Molecular Medicine, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90033 and.
Pandey NK; Biochemistry and Molecular Medicine, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90033 and.
Situ AJ; From the Departments of Physiology and Neuroscience and.
Ulmer TS; From the Departments of Physiology and Neuroscience and.
Langen R; From the Departments of Physiology and Neuroscience and.

J Biol Chem ; 293(51): 19613-19623, 2018 12 21.

Article em En | MEDLINE | ID: mdl-30315108

Assuntos

Éxons; Proteína Huntingtina/química; Proteína Huntingtina/genética; Peptídeos; Dobramento de Proteína; Humanos; Modelos Moleculares; Conformação Proteica em alfa-Hélice; Temperatura

Palavras-chave

Huntington disease; conformational equilibrium; electron paramagnetic resonance (EPR); neurodegeneration; nuclear magnetic resonance (NMR); polyglutamine; protein misfolding

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Éxons / Dobramento de Proteína / Proteína Huntingtina Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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