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The predictive value of the inflammatory markers P-selectin and MCP1 in determining the length of stay and 30-day survival in the differentiation of sepsis patients.
Duman, Ali; Turkdogan, Kenan Ahmet; Avcil, Mucahit; Yenisey, Cigdem; Ture, Mevlut; Akoz, Ayhan; Dagli, Bekir; Kapci, Mucahit; Orun, Serhat.
Afiliação
  • Duman A; Department of Faculty of Medicine, Adnan Menderes Universtiy, Aydin.
  • Turkdogan KA; Department of Faculty of Medicine, Adnan Menderes Universtiy, Aydin.
  • Avcil M; Department of Faculty of Medicine, Adnan Menderes Universtiy, Aydin.
  • Yenisey C; Department of Biochemistry, Adnan Menderes Universtiy, Aydin.
  • Ture M; Department of Biochemistry, Adnan Menderes Universtiy, Aydin.
  • Akoz A; Department of Faculty of Medicine, Adnan Menderes Universtiy, Aydin.
  • Dagli B; Department of Emergency Medicine, Adnan Menderes Universtiy, Aydin.
  • Kapci M; Department of Emergency Medicine, Adnan Menderes Universtiy, Aydin.
  • Orun S; Emergecy Service, Bandirma State Hospital, Balikesir, Turkey.
J Pak Med Assoc ; 68(9): 1321-1326, 2018 Sep.
Article em En | MEDLINE | ID: mdl-30317258
OBJECTIVE: Sepsis is the leading disease that is diagnosed late and still has a mortal course in emergency departments. The primary factors that will reduce both morbidity and mortality are early diagnosis and an early treatment approach. Therefore, in this study, P-selectin and MCP1 levels, which are known to be markers of inflammation, were examined in patients being followed up in intensive care. METHODS: Patients evaluated with a preliminary diagnosis of sepsis in the emergency intensive care unit between September 2015 and August 2016 were classified as having sepsis or infection according to the Q- SOFA criteria, and the P- selectin values were compared. RESULTS: In the sepsis group, GCS was determined as 13 (12-13), SBP 90 (80-110), tachypnea 24 (22-26), lactate 3.8 (0.6-16.0), MAP 70 (60-77), and LOS 16 days (9.5-20.3). In the ROC analysis, the sensitivity of P-selectin and MCP1 in the differentiation of patients with and without sepsis was 95.7%, and 73.8%, and the specificity was 97.8% and 73.8%, respectively. According to the cutoff values, the sensitivity and specificity in the prediction of patient mortality were 71.4% and 65.6% in P- selectin and 78.6% and 65.6% in MCP1. CONCLUSIONS: The P-selectin and MCP1 values in the emergency department can differentiate sepsis patients according to the Q-SOFA criteria and showed 30-day mortality at a significant level. Therefore, in patients with suspected sepsis in an emergency department, MCP1 can be of benefit to physicians in their decisions regarding LOS and transfer to intensive care.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sepse / Selectina-P / Infecções Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Ano de publicação: 2018 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sepse / Selectina-P / Infecções Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Ano de publicação: 2018 Tipo de documento: Article