Telomere length and childhood trauma in Colombians with depressive symptoms.
Braz J Psychiatry
; 41(3): 194-198, 2019.
Article
em En
| MEDLINE
| ID: mdl-30328966
ABSTRACT
OBJECTIVE:
Childhood trauma and telomere length (TL) are important risk factors for major depressive disorder. We examined whether there was an association between childhood trauma and TL in a sample of Colombians who were assessed for depressive symptoms.METHODS:
We applied the Center for Epidemiologic Studies Depression scale, the Patient Health Questionnaire-9, the Hospital Anxiety and Depression scale and the Childhood Trauma Questionnaire to 92 Colombian subjects (mean age = 21). TL was measured with quantitative PCR. Spearman's correlation coefficient (rs) was used to analyze the relationship between childhood trauma scores and TL.RESULTS:
We found a significant correlation between TL and sexual abuse scores (rs = 0.428, p = 0.002) in individuals with higher depressive symptom scores.CONCLUSION:
This is the first report of a significant association between TL and sexual abuse in a Latin American sample and provides additional evidence about the role of childhood trauma and TL in neuropsychiatric disorders.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Maus-Tratos Infantis
/
Telômero
/
Transtorno Depressivo Maior
/
Encurtamento do Telômero
Tipo de estudo:
Diagnostic_studies
/
Qualitative_research
/
Risk_factors_studies
Limite:
Adult
/
Child
/
Female
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Colombia
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article