Tracking intracellular dynamics through extracellular measurements.
PLoS One
; 13(10): e0205031, 2018.
Article
em En
| MEDLINE
| ID: mdl-30332448
ABSTRACT
Extracellular recordings of neuronal cells are frequently a part of in vitro and in vivo experimental studies as a means of monitoring network-level dynamics. Their connections to intracellular dynamics are not well understood. Single-unit recordings are a more direct way to measure intracellular dynamics, but are typically difficult and expensive. On the other hand, simple differential equations models exist for single neurons. In this article, we apply a recent advance in data assimilation theory, designed to correct bias in general observation functions, toward the reconstruction of model-based intracellular dynamics from extracellular recordings.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Modelos Neurológicos
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article