Synthesis and properties of a lysosome-targeting fluorescent ionophore based on coumarins and squaramides.
Org Biomol Chem
; 16(43): 8025-8029, 2018 11 07.
Article
em En
| MEDLINE
| ID: mdl-30334042
ABSTRACT
In this paper we present the first example of a lysosome-targeting fluorescent ionophore. Specifically, we synthesized a squaramide derivative bearing a coumarin fluorophore and a morpholinyl group, and found that it was able to target and efficiently deacidify lysosomes. In contrast, an analogue without a morpholinyl group exhibits much lower ability to localize in lysosomes and is much less active in regulating the lysosomal pH.
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Coleções:
01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article