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PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake.
Parhiz, Hamideh; Shuvaev, Vladimir V; Pardi, Norbert; Khoshnejad, Makan; Kiseleva, Raisa Yu; Brenner, Jacob S; Uhler, Thomas; Tuyishime, Steven; Mui, Barbara L; Tam, Ying K; Madden, Thomas D; Hope, Michael J; Weissman, Drew; Muzykantov, Vladimir R.
Afiliação
  • Parhiz H; Department of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: parhizh@pennmedicine.upenn.edu.
  • Shuvaev VV; Department of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Pardi N; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Khoshnejad M; Department of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Kiseleva RY; Department of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Brenner JS; Department of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Uhler T; Department of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Tuyishime S; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Mui BL; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada.
  • Tam YK; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada.
  • Madden TD; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada.
  • Hope MJ; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada.
  • Weissman D; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: dreww@upenn.edu.
  • Muzykantov VR; Department of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: muzykant@mail.med.upenn.edu.
J Control Release ; 291: 106-115, 2018 12 10.
Article em En | MEDLINE | ID: mdl-30336167
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apolipoproteínas E / RNA Mensageiro / Endotélio Vascular / Sistemas de Liberação de Medicamentos / Molécula-1 de Adesão Celular Endotelial a Plaquetas / Nanopartículas Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apolipoproteínas E / RNA Mensageiro / Endotélio Vascular / Sistemas de Liberação de Medicamentos / Molécula-1 de Adesão Celular Endotelial a Plaquetas / Nanopartículas Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article