Analysis of the nitric oxide-cyclic guanosine monophosphate pathway in experimental liver cirrhosis suggests phosphodiesterase-5 as potential target to treat portal hypertension.

Schaffner, Denise; Lazaro, Adhara; Deibert, Peter; Hasselblatt, Peter; Stoll, Patrick; Fauth, Lisa; Baumstark, Manfred W; Merfort, Irmgard; Schmitt-Graeff, Annette; Kreisel, Wolfgang

Schaffner, Denise; Lazaro, Adhara; Deibert, Peter; Hasselblatt, Peter; Stoll, Patrick; Fauth, Lisa; Baumstark, Manfred W; Merfort, Irmgard; Schmitt-Graeff, Annette; Kreisel, Wolfgang.

Afiliação

Schaffner D; Institute for Exercise-und Occupational Medicine, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.
Lazaro A; Institute for Exercise-und Occupational Medicine, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.
Deibert P; Institute for Exercise-und Occupational Medicine, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.
Hasselblatt P; Department of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.
Stoll P; Anaesthesiological Practice, Freiburg 79104, Germany.
Fauth L; Institute of Clinical Pathology, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.
Baumstark MW; Institute for Exercise-und Occupational Medicine, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.
Merfort I; Department of Pharmaceutical Biology and Biotechnology, University of Freiburg, Freiburg 79104, Germany.
Schmitt-Graeff A; Institute of Clinical Pathology, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.
Kreisel W; Department of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany. wolfgang.kreisel@uniklinik-freiburg.de.

World J Gastroenterol ; 24(38): 4356-4368, 2018 Oct 14.

Article em En | MEDLINE | ID: mdl-30344420

Assuntos

Nucleotídeo Cíclico Fosfodiesterase do Tipo 5/metabolismo; Hipertensão Portal/tratamento farmacológico; Cirrose Hepática Experimental/complicações; Inibidores da Fosfodiesterase 5/farmacologia; Transdução de Sinais/efeitos dos fármacos; Animais; GMP Cíclico/sangue; GMP Cíclico/metabolismo; Guanosina Monofosfato/metabolismo; Humanos; Hipertensão Portal/sangue; Hipertensão Portal/etiologia; Hipertensão Portal/patologia; Fígado/efeitos dos fármacos; Fígado/metabolismo; Fígado/patologia; Cirrose Hepática Experimental/sangue; Cirrose Hepática Experimental/induzido quimicamente; Cirrose Hepática Experimental/patologia; Masculino; Óxido Nítrico/metabolismo; Óxido Nítrico Sintase/metabolismo; Inibidores da Fosfodiesterase 5/uso terapêutico; Ratos; Ratos Sprague-Dawley; Ratos Wistar; Citrato de Sildenafila/farmacologia; Citrato de Sildenafila/uso terapêutico; Tioacetamida/toxicidade; Resultado do Tratamento

Palavras-chave

Cyclic guanosine monophosphate; Hepatic stellate cells; Liver cirrhosis; Metabolic zonation; Nitric oxide; Phosphodiesterase-5; Portal hypertension; Sildenafil; Thioacetamide

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Nucleotídeo Cíclico Fosfodiesterase do Tipo 5 / Inibidores da Fosfodiesterase 5 / Hipertensão Portal / Cirrose Hepática Experimental Tipo de estudo: Etiology_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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