Spatiotemporal Loss of <i>NF1</i> in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway.

Chen, Zhiguo; Mo, Juan; Brosseau, Jean-Philippe; Shipman, Tracey; Wang, Yong; Liao, Chung-Ping; Cooper, Jonathan M; Allaway, Robert J; Gosline, Sara J C; Guinney, Justin; Carroll, Thomas J; Le, Lu Q

Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway.

Chen, Zhiguo; Mo, Juan; Brosseau, Jean-Philippe; Shipman, Tracey; Wang, Yong; Liao, Chung-Ping; Cooper, Jonathan M; Allaway, Robert J; Gosline, Sara J C; Guinney, Justin; Carroll, Thomas J; Le, Lu Q.

Afiliação

Chen Z; Department of Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas.
Mo J; Department of Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas.
Brosseau JP; Department of Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas.
Shipman T; Department of Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas.
Wang Y; Department of Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas.
Liao CP; Department of Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas.
Cooper JM; Department of Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas.
Allaway RJ; Sage Bionetworks, Seattle, Washington.
Gosline SJC; Sage Bionetworks, Seattle, Washington.
Guinney J; Sage Bionetworks, Seattle, Washington.
Carroll TJ; Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, Texas.
Le LQ; Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, Texas.

Cancer Discov ; 9(1): 114-129, 2019 01.

Article em En | MEDLINE | ID: mdl-30348677

Assuntos

Neurofibroma/metabolismo; Neurofibromatose 1/metabolismo; Neurofibromina 1/genética; Proteínas Serina-Treonina Quinases/metabolismo; Células de Schwann/metabolismo; Transdução de Sinais; Neoplasias Cutâneas/metabolismo; Animais; Linhagem da Célula; Modelos Animais de Doenças; Feminino; Via de Sinalização Hippo; Masculino; Camundongos; Camundongos Knockout; Mutação; Neurofibroma/etiologia; Neurofibroma/genética; Neurofibroma/fisiopatologia; Neurofibroma Plexiforme/etiologia; Neurofibroma Plexiforme/genética; Neurofibroma Plexiforme/metabolismo; Neurofibroma Plexiforme/fisiopatologia; Neurofibromatose 1/complicações; Neurofibromatose 1/genética; Neurofibromatose 1/fisiopatologia; Células de Schwann/fisiologia; Neoplasias Cutâneas/etiologia; Neoplasias Cutâneas/genética; Neoplasias Cutâneas/fisiopatologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células de Schwann / Neoplasias Cutâneas / Transdução de Sinais / Neurofibromatose 1 / Proteínas Serina-Treonina Quinases / Neurofibromina 1 / Neurofibroma Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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