Mixed signals from the cell's antennae: primary cilia in cancer.
EMBO Rep
; 19(11)2018 11.
Article
em En
| MEDLINE
| ID: mdl-30348893
ABSTRACT
Primary cilia (PC) are antenna-like organelles that protrude from most mammalian cells. They are essential for the regulation of several signaling pathways such as Hedgehog and WNT It is therefore not surprising that a dysfunction of PC is frequently associated with pathologies. Originally, PC were found to be involved in a variety of diseases commonly referred to as ciliopathies including cystic kidney diseases. Evidence is accumulating that PC play also an important role in cancer formation and regulation, which is the focus of this review.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cílios
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Neoplasias
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article