Antigen discovery and specification of immunodominance hierarchies for MHCII-restricted epitopes.

Graham, Daniel B; Luo, Chengwei; O'Connell, Daniel J; Lefkovith, Ariel; Brown, Eric M; Yassour, Moran; Varma, Mukund; Abelin, Jennifer G; Conway, Kara L; Jasso, Guadalupe J; Matar, Caline G; Carr, Steven A; Xavier, Ramnik J

Graham, Daniel B; Luo, Chengwei; O'Connell, Daniel J; Lefkovith, Ariel; Brown, Eric M; Yassour, Moran; Varma, Mukund; Abelin, Jennifer G; Conway, Kara L; Jasso, Guadalupe J; Matar, Caline G; Carr, Steven A; Xavier, Ramnik J.

Afiliação

Graham DB; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA. dgraham@broadinstitute.org.
Luo C; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. dgraham@broadinstitute.org.
O'Connell DJ; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. dgraham@broadinstitute.org.
Lefkovith A; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA, USA. dgraham@broadinstitute.org.
Brown EM; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Yassour M; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Varma M; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Abelin JG; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Conway KL; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Jasso GJ; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Matar CG; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Carr SA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Xavier RJ; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.

Nat Med ; 24(11): 1762-1772, 2018 11.

Article em En | MEDLINE | ID: mdl-30349087

Assuntos

Apresentação de Antígeno/imunologia; Antígenos de Histocompatibilidade Classe II/genética; Epitopos Imunodominantes/genética; Proteômica; Sequência de Aminoácidos/genética; Apresentação de Antígeno/genética; Linfócitos T CD4-Positivos/imunologia; Epitopos de Linfócito T/genética; Epitopos de Linfócito T/imunologia; Sequenciamento de Nucleotídeos em Larga Escala; Antígenos de Histocompatibilidade Classe II/imunologia; Humanos; Epitopos Imunodominantes/imunologia; Listeria monocytogenes/genética; Listeria monocytogenes/imunologia; Listeria monocytogenes/patogenicidade; Receptores de Antígenos de Linfócitos T/genética; Receptores de Antígenos de Linfócitos T/imunologia; Análise de Célula Única

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígenos de Histocompatibilidade Classe II / Epitopos Imunodominantes / Apresentação de Antígeno / Proteômica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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