Selective inhibition of nociceptive flexion reflex discharge by the kappa agonist bremazocine.
Neuropharmacology
; 26(2-3): 271-4, 1987.
Article
em En
| MEDLINE
| ID: mdl-3035416
ABSTRACT
In unanaesthetized decerebrate spinal cats, bremazocine (0.012-0.2 mg/kg, i.v.) selectively inhibited the late C-fibre reflex discharge, recorded in sectioned lumbo-sacral ventral root filaments, after supramaximal electrical stimulation of the ipsilateral sural or common peroneal nerve. This action was naloxone-reversible. The results suggest that activation of kappa opioid receptors in the spinal cord inhibits the integration of nociceptive, but not locomotor, flexion reflexes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nervos Espinhais
/
Benzomorfanos
/
Receptores Opioides
/
Analgésicos
/
Morfinanos
Limite:
Animals
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article