Life-threatening vitamin D intoxication due to intake of ultra-high doses in multiple sclerosis: A note of caution.
Mult Scler
; 25(9): 1326-1328, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-30358476
ABSTRACT
Knowledge about complications of chronic ultra-high dose vitamin D supplementation is limited. We report a patient with primary progressive multiple sclerosis (MS) who presented with generalized weakness caused by hypercalcemia after uncontrolled intake of more than 50,000 IU of cholecalciferol per day over several months. Various treatment strategies were required to achieve normocalcemia. However, renal function improved only partly and further progression of MS was observed. We conclude that patients need to be informed about the risks of uncontrolled vitamin D intake and neurologists need to be alert of biochemical alterations and symptoms of vitamin D toxicity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitaminas
/
Colecalciferol
/
Esclerose Múltipla Crônica Progressiva
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Hipercalcemia
Tipo de estudo:
Etiology_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article