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Dengue Virus Inhibition Targets: A Review and Docking Study.
Scotti, Luciana; Scotti, Marcus Tullius; Yarla, Nagendra Sastry; Monteiro, Alex France Messias; de Oliveira Viana, Jessika; Dantzger, Derli Ranieri Costa; Ishiki, Hamilton Mitsugu.
Afiliação
  • Scotti L; Federal University of Paraiba, Health Sci. Center, 50670-910, Joao Pessoa, PB, Brazil.
  • Scotti MT; Teaching and Research Management - University Hospital, Federal University of Paraíba, João Pessoa, PB, Brazil.
  • Yarla NS; Federal University of Paraiba, Health Sci. Center, 50670-910, Joao Pessoa, PB, Brazil.
  • Monteiro AFM; GITAM University, Visakhapatnam, A.P, India.
  • de Oliveira Viana J; Federal University of Paraiba, Health Sci. Center, 50670-910, Joao Pessoa, PB, Brazil.
  • Dantzger DRC; Federal University of Paraiba, Health Sci. Center, 50670-910, Joao Pessoa, PB, Brazil.
  • Ishiki HM; University of Western Sao Paulo (UNOESTE), Presidente Prudente, Sao Paulo, Brazil.
Curr Top Med Chem ; 18(18): 1522-1530, 2018.
Article em En | MEDLINE | ID: mdl-30360718
Dengue like any neglected tropical disease affects a large part of the world population. In this disease, the infection is caused by arboviruses transmitted by the A. aegypti and A. albopictus mosquito, in which its most severe manifestation is known as dengue hemorrhagic fever. The infected person presents symptoms characteristic of such as fever and rash. Among the ways of fighting dengue by bioactives is the inhibition of NS2B-NS3 protease, inhibition of protein E, and inhibition of sclerotization of the vector cuticle. The cuticle is indispensable for the survival of the mosquito that can be compromised through the inhibition of arylalkylamine N-acetyltransferase (aaNAT). In the studies shown, in silico tests were performed as molecular docking, functional density analysis, molecular orbitals energies with the analyses of the interactions between bioactives and the targets studied. However, in addition to discussing the fight against dengue virus infection through different routes, in this paper, some in silico results of 27 analogs of myricetin have been presented, which showed action on the cuticle sclerotization mechanism.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Vírus da Dengue / Simulação de Acoplamento Molecular Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Vírus da Dengue / Simulação de Acoplamento Molecular Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article