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The role of long-wavelength ultraviolet A1 (UVA1) in acral vitiligo.
El-Zawahry, Bakr Mohamed; Elmasry, Maha Fathy; Ragab, Amira.
Afiliação
  • El-Zawahry BM; Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Elmasry MF; Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Ragab A; Dermatology Department, El Haud El Marsoud Hospital, Cairo, Egypt.
J Cosmet Dermatol ; 18(4): 1155-1160, 2019 Aug.
Article em En | MEDLINE | ID: mdl-30375144
INTRODUCTION: Acral vitiligo is a resistant subtype of vitiligo that does not respond easily to any treatment modality. Ultraviolet A1 (UVA1) (340-400 nm) therapy can penetrate the deep dermis of the skin and is relatively free of adverse effects associated with different phototherapeutic modalities. This study's objective was to evaluate the effect of medium-dose long-wavelength UVA1 (40-70 J) in acral vitiligo treatment and compare it with topical psoralen plus ultraviolet A (topical PUVA). METHODS: Patients in this randomized-controlled comparative clinical trial were divided into two groups, medium-dose UVA1 group and topical PUVA group (10 acral vitiligo patients each). Patients received 36 sessions of phototherapy over a period of 12 weeks. Every patient was clinically evaluated monthly as regards the appearance of new lesions or increase in diameter of the current lesion according to point counting and vitiligo area severity index. RESULTS: No statistically significant clinical difference was found between patients in UVA1 and topical PUVA groups regarding response and pattern of response (P > 0.05). CONCLUSION: Ultraviolet A1 seems to be of limited use as a monotherapy in acral vitiligo treatment. However, more studies combining it with other treatment modalities as systemic steroids and/or using higher UVA1 doses may prove beneficial.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia PUVA / Terapia Ultravioleta / Vitiligo / Fármacos Fotossensibilizantes / Ficusina Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia PUVA / Terapia Ultravioleta / Vitiligo / Fármacos Fotossensibilizantes / Ficusina Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article