Habitual exercisers versus sedentary subjects with Parkinson's Disease: Multimodal PET and fMRI study.
Mov Disord
; 33(12): 1945-1950, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-30376184
ABSTRACT
BACKGROUND:
The benefits of exercise in PD have been linked to enhanced dopamine (DA) transmission in the striatum.OBJECTIVE:
To examine differences in DA release, reward signaling, and clinical features between habitual exercisers and sedentary subjects with PD.METHODS:
Eight habitual exercisers and 9 sedentary subjects completed [11 C]raclopride PET scans before and after stationary cycling to determine exercise-induced release of endogenous DA in the dorsal striatum. Additionally, functional MRI assessed ventral striatum activation during reward anticipation. All participants completed motor (UPDRS III; finger tapping; and timed-up-and-go) and nonmotor (Beck Depression Inventory; Starkstein Apathy Scale) assessments.RESULTS:
[11 C]Raclopride analysis before and after stationary cycling demonstrated greater DA release in the caudate nuclei of habitual exercisers compared to sedentary subjects (P < 0.05). Habitual exercisers revealed greater activation of ventral striatum during the functional MRI reward task (P < 0.05) and lower apathy (P < 0.05) and bradykinesia (P < 0.05) scores versus sedentary subjects.CONCLUSIONS:
Habitual exercise is associated with preservation of motor and nonmotor function, possibly mediated by increased DA release. This study formulates a foundation for prospective, randomized controlled studies. © 2018 International Parkinson and Movement Disorder Society.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Imageamento por Ressonância Magnética
Tipo de estudo:
Clinical_trials
Limite:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article