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Discovery and Structure-Activity Relationships of N-Aryl 6-Aminoquinoxalines as Potent PFKFB3 Kinase Inhibitors.
Boutard, Nicolas; Bialas, Arkadiusz; Sabiniarz, Aleksandra; Guzik, Pawel; Banaszak, Katarzyna; Biela, Artur; Bien, Marcin; Buda, Anna; Bugaj, Barbara; Cieluch, Ewelina; Cierpich, Anna; Dudek, Lukasz; Eggenweiler, Hans-Michael; Fogt, Joanna; Gaik, Monika; Gondela, Andrzej; Jakubiec, Krzysztof; Jurzak, Mirek; Kitlinska, Agata; Kowalczyk, Piotr; Kujawa, Maciej; Kwiecinska, Katarzyna; Les, Marcin; Lindemann, Ralph; Maciuszek, Monika; Mikulski, Maciej; Niedziejko, Paulina; Obara, Alicja; Pawlik, Henryk; Rzymski, Tomasz; Sieprawska-Lupa, Magdalena; Sowinska, Marta; Szeremeta-Spisak, Joanna; Stachowicz, Agata; Tomczyk, Mateusz M; Wiklik, Katarzyna; Wloszczak, Lukasz; Ziemianska, Sylwia; Zarebski, Adrian; Brzózka, Krzysztof; Nowak, Mateusz; Fabritius, Charles-Henry.
Afiliação
  • Boutard N; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Bialas A; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Sabiniarz A; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Guzik P; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Banaszak K; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Biela A; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Bien M; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Buda A; Current address: Almac Group, 20 Seagoe Industrial Estate, Craigavon, BT63 5QD, UK.
  • Bugaj B; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Cieluch E; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Cierpich A; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Dudek L; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Eggenweiler HM; Current address: Grupa Azoty S.A., Kwiatkowskiego 8, 33-100, Tarnów, Poland.
  • Fogt J; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Gaik M; Medicinal Chemistry, Merck Biopharma, Merck KGaA, Frankfurter Straße 250, 64293, Darmstadt, Germany.
  • Gondela A; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Jakubiec K; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Jurzak M; Current address: Max Planck Research Group at the Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.
  • Kitlinska A; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Kowalczyk P; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Kujawa M; Discovery Pharmacology, Merck Biopharma, Merck KGaA, Frankfurter Straße 250, 64293, Darmstadt, Germany.
  • Kwiecinska K; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Les M; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Lindemann R; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Maciuszek M; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Mikulski M; Current address: Captor Therapeutics, Dunska 11, 54-427, Wroclaw, Poland.
  • Niedziejko P; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Obara A; Translational Innovation Platform Oncology, Merck Biopharma, Merck KGaA, Frankfurter Straße 250, 64293, Darmstadt, Germany.
  • Pawlik H; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Rzymski T; Current address: LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK.
  • Sieprawska-Lupa M; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Sowinska M; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Szeremeta-Spisak J; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Stachowicz A; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Tomczyk MM; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Wiklik K; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Wloszczak L; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Ziemianska S; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Zarebski A; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Brzózka K; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
  • Nowak M; Current address: Katedra Chemii Organicznej, Bioorganicznej I Biotechnologii, Ul. B. Krzywoustego 4, P., 18/N1, 44-100, Gliwice, Poland.
  • Fabritius CH; Selvita S.A., Bobrzynskiego 14, 30-348, Kraków, Poland.
ChemMedChem ; 14(1): 169-181, 2019 01 08.
Article em En | MEDLINE | ID: mdl-30378281
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinoxalinas / Fosfofrutoquinase-2 / Inibidores Enzimáticos / Descoberta de Drogas Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinoxalinas / Fosfofrutoquinase-2 / Inibidores Enzimáticos / Descoberta de Drogas Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article