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Palladium-Catalyzed Carbon Isotope Exchange on Aliphatic and Benzoic Acid Chlorides.
Gauthier, Donald R; Rivera, Nelo R; Yang, Haifeng; Schultz, Danielle M; Shultz, C Scott.
Afiliação
  • Gauthier DR; Department of Process Research and Development , Merck & Co., Inc. , Rahway , New Jersey 07065 , United States.
  • Rivera NR; Department of Process Research and Development , Merck & Co., Inc. , Rahway , New Jersey 07065 , United States.
  • Yang H; Department of Process Research and Development , Merck & Co., Inc. , Rahway , New Jersey 07065 , United States.
  • Schultz DM; Department of Process Research and Development , Merck & Co., Inc. , Rahway , New Jersey 07065 , United States.
  • Shultz CS; Department of Process Research and Development , Merck & Co., Inc. , Rahway , New Jersey 07065 , United States.
J Am Chem Soc ; 140(46): 15596-15600, 2018 11 21.
Article em En | MEDLINE | ID: mdl-30384591
ABSTRACT
An operationally simple protocol for a palladium-catalyzed 13CO and 14CO exchange with activated aliphatic and benzoic carbonyls is presented. Several 13C and 14C building blocks, natural product derivatives, and pharmaceuticals have been prepared to showcase the method for late-stage carbon isotope incorporation and its functional group compatibility.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article