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Central Circadian Clock Regulates Energy Metabolism.
Ding, Guolian; Gong, Yingyun; Eckel-Mahan, Kristin L; Sun, Zheng.
Afiliação
  • Ding G; International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • Gong Y; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
  • Eckel-Mahan KL; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
  • Sun Z; Department of Endocrinology and Metabolism, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Adv Exp Med Biol ; 1090: 79-103, 2018.
Article em En | MEDLINE | ID: mdl-30390286
Our body not only responds to environmental changes but also anticipates them. The light and dark cycle with the period of about 24 h is a recurring environmental change that determines the diurnal variation in food availability and safety from predators in nature. As a result, the circadian clock is evolved in most animals to align locomotor behaviors and energy metabolism with the light cue. The central circadian clock in mammals is located at the suprachiasmatic nucleus (SCN) of the hypothalamus in the brain. We here review the molecular and anatomic architecture of the central circadian clock in mammals, describe the experimental and observational evidence that suggests a critical role of the central circadian clock in shaping systemic energy metabolism, and discuss the involvement of endocrine factors, neuropeptides, and the autonomic nervous system in the metabolic functions of the central circadian clock.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Núcleo Supraquiasmático / Metabolismo Energético / Relógios Circadianos Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Núcleo Supraquiasmático / Metabolismo Energético / Relógios Circadianos Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article