Estrogenic regulation of social behavior and sexually dimorphic brain formation.
Neurosci Biobehav Rev
; 110: 46-59, 2020 03.
Article
em En
| MEDLINE
| ID: mdl-30392880
ABSTRACT
It has long been known that the estrogen, 17ß-estradiol (17ß-E), plays a central role for female reproductive physiology and behavior. Numerous studies have established the neurochemical and molecular basis of estrogenic induction of female sexual behavior, i.e., lordosis, in animal models. In addition, 17ß-E also regulates male-type sexual and aggressive behavior. In males, testosterone secreted from the testes is irreversibly aromatized to 17ß-E in the brain. We discuss the contribution of two nuclear receptor isoforms, estrogen receptor (ER)α and ERß to the estrogenic regulation of sexually dimorphic brain formation and sex-typical expression of these social behaviors. Furthermore, 17ß-E is a key player for social behaviors such as social investigation, preference, recognition and memory as well as anxiety-related behaviors in social contexts. Recent studies also demonstrated that not only nuclear receptor-mediated genomic signaling but also membrane receptor-mediated non-genomic actions of 17ß-E may underlie the regulation of these behaviors. Finally, we will discuss how rapidly developing research tools and ideas allow us to investigate estrogenic action by emphasizing behavioral neural networks.
Palavras-chave
17ß-estradiol; Aggressive behavior; Dendritic spines; Estrogen receptorα; Estrogen receptorß; Genomic action; Hippocampus; Hypothalamus; Membrane-mediated non-genomic action; Parental behavior; Sexual behavior; Sexually dimorphic nuclei; Social behavioral networks; Social learning; Social recognition; Testosterone
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comportamento Social
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Reconhecimento Psicológico
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Estrogênios
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Memória
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article