Nuclear Factor Erythroid 2-Related Factor 2 Activating Triterpenoid Saponins from Camellia japonica Roots.
J Nat Prod
; 81(11): 2399-2409, 2018 11 26.
Article
em En
| MEDLINE
| ID: mdl-30395460
ABSTRACT
Oxidative stress due to the presence of excess reactive oxygen species may cause cancers, aging, and many other conditions. Nuclear factor erythroid 2-related factor 2 (Nrf2) may control abnormal oxidative stress as a transcription factor by inducing antioxidant-related genes via antioxidant response elements (AREs) in the gene promoters. The 11 triterpenoid saponins (1-11) isolated from Camellia japonica roots were tested for ARE-luciferase activity and Nrf2 accumulation in human keratinocytes (HaCaT cells). The ARE-luciferase activity was significantly increased by compounds 1-11 (25 µM) as a result of nuclear Nrf2 accumulation in the cells. Thus, these compounds may contribute to the induction of Nrf2 activity against oxidative damage in cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saponinas
/
Triterpenos
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Raízes de Plantas
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Camellia
/
Fator 2 Relacionado a NF-E2
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article