Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer.
Nat Commun
; 9(1): 4664, 2018 11 07.
Article
em En
| MEDLINE
| ID: mdl-30405135
ABSTRACT
PD-L1 immunohistochemistry correlates only moderately with patient survival and response to PD-(L)1 treatment. Heterogeneity of tumor PD-L1 expression might limit the predictive value of small biopsies. Here we show that tumor PD-L1 and PD-1 expression can be quantified non-invasively using PET-CT in patients with non-small-cell lung cancer. Whole body PD-(L)1 PET-CT reveals significant tumor tracer uptake heterogeneity both between patients, as well as within patients between different tumor lesions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma Pulmonar de Células não Pequenas
/
Tomografia por Emissão de Pósitrons
/
Imagem Corporal Total
/
Antígeno B7-H1
/
Receptor de Morte Celular Programada 1
/
Neoplasias Pulmonares
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article