Angiotensin II and the Natriuretic and Blood Pressure Response to Mental Stress in African Americans.
Ethn Dis
; 28(4): 511-516, 2018.
Article
em En
| MEDLINE
| ID: mdl-30405294
ABSTRACT
Objective:
To test the hypothesis that Angiotensin II (Ang II) is a contributing factor to the response pattern in African Americans (AAs) who retain rather than excrete sodium during mental stress. Design/StudyParticipants:
Double-blind, randomized, cross-over trial of 87 healthy AAs aged 18 to 50 years.Interventions:
The study participants received either a placebo or irbesartan, (150 mg PO), an Ang II receptor antagonist, for seven days prior to stress testing. Urinary sodium excretion (UNaV) and systolic blood pressure (SBP) were collected prior to and throughout a mental stress protocol (rest and stress period).Setting:
A southeastern university. Main OutcomeMeasures:
Ang II, SBP, and sodium retention.Results:
During the placebo condition, 62 participants showed the expected increase in UNaV (excreters) while 25 participants reduced UNaV during stress (retainers). Irbesartan retainers demonstrated a reversal in the direction of their natriuretic response, now increasing UNaV in response to stress (∆ UNaV of -.094 mmol/min with placebo vs .052 mmol/min on irbesartan; P<.001). In excreters, irbesartan reduced SBP levels during both rest (-2.36 mm Hg; P=.03) and stress (-4.59;P<.0001), and an even more pronounced reduction in SBP was demonstrated by retainers on treatment during both rest (-4.29 mm Hg; P=.03) and stress (-6.12; P<.001).Conclusions:
Ang II contributes to sodium retention in retainers. Furthermore, our findings indicate that suppression of Ang II has a beneficial effect on SBP during rest and stress in this population.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sódio
/
Estresse Psicológico
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Negro ou Afro-Americano
/
Pressão Sanguínea
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Angiotensina II
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Eliminação Renal
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Irbesartana
Tipo de estudo:
Clinical_trials
/
Guideline
Limite:
Adult
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Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article