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Photoresponsive, Water-Soluble Supramolecular Dendronized Polymer with Specific Lysosome-Targetable Bioimaging Application in Living Cells.
Li, Hang; Wu, Jie; Yin, Jia-Fu; Wang, Huan; Wu, Yongquan; Kuang, Gui-Chao.
Afiliação
  • Li H; State Key laboratory of Power metallurgy, Central South University, Lushan South Road 932, Yuelu District, Changsha, Hunan, 410083, P. R. China.
  • Wu J; Key Laboratory of Organo-pharmaceutical Chemistry, School of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, Jiangxi, 341000, China.
  • Yin JF; State Key laboratory of Power metallurgy, Central South University, Lushan South Road 932, Yuelu District, Changsha, Hunan, 410083, P. R. China.
  • Wang H; State Key laboratory of Power metallurgy, Central South University, Lushan South Road 932, Yuelu District, Changsha, Hunan, 410083, P. R. China.
  • Wu Y; Key Laboratory of Organo-pharmaceutical Chemistry, School of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, Jiangxi, 341000, China.
  • Kuang GC; State Key laboratory of Power metallurgy, Central South University, Lushan South Road 932, Yuelu District, Changsha, Hunan, 410083, P. R. China.
Macromol Rapid Commun ; 40(3): e1800714, 2019 Feb.
Article em En | MEDLINE | ID: mdl-30408258
ABSTRACT
A novel photoresponsive, water-soluble supramolecular dendronized polymer (SDP) is prepared through a γ -cyclodextrin (γ -CD)-coumarin host-guest interaction. The supramolecular formation, photoresponsive process, and fluorescence properties are investigated by nuclear magnetic resonance (NMR) techniques and spectrometric measurements. Upon different-wavelength light irradiation, this supramolecular polymer undergoes noncovalent polymer and covalent polymer conversion due to coumarin cycloaddition and cleavage reactions. In addition, SDP for bioimaging in Michigan Cancer Foundation-7 (MCF-7) cells is performed and results show that the obtained SDP has good biocompatibility and is lysosome-targetable. This research enriches the field of supramolecular dendrimers and the photo-stimulation response material may have application prospects in organelle-targeting applications.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polímeros / Água / Dendrímeros / Lisossomos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polímeros / Água / Dendrímeros / Lisossomos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article