Discovery of novel quinazolines as potential anti-tubulin agents occupying three zones of colchicine domain.

Li, Wenlong; Yin, Ying; Shuai, Wen; Xu, Feijie; Yao, Hong; Liu, Jie; Cheng, Keguang; Xu, Jinyi; Zhu, Zheying; Xu, Shengtao

Li, Wenlong; Yin, Ying; Shuai, Wen; Xu, Feijie; Yao, Hong; Liu, Jie; Cheng, Keguang; Xu, Jinyi; Zhu, Zheying; Xu, Shengtao.

Afiliação

Li W; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
Yin Y; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
Shuai W; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
Xu F; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
Yao H; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
Liu J; Department of Organic Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, and School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004, PR China.
Cheng K; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, and School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004, PR China.
Xu J; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China. Electronic address: jinyixu@china.com.
Zhu Z; Division of Molecular Therapeutics & Formulation, School of Pharmacy, The University of Nottingham, University Park Campus, Nottingham NG7 2RD, UK. Electronic address: Zheying.Zhu@nottingham.ac.uk.
Xu S; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China. Electronic address: cpuxst@163.com.

Bioorg Chem ; 83: 380-390, 2019 03.

Article em En | MEDLINE | ID: mdl-30408650

Assuntos

Antineoplásicos/farmacologia; Quinazolinas/farmacologia; Moduladores de Tubulina/farmacologia; Animais; Antineoplásicos/síntese química; Antineoplásicos/metabolismo; Apoptose/efeitos dos fármacos; Sítios de Ligação; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Pontos de Checagem da Fase G2 do Ciclo Celular/efeitos dos fármacos; Células Endoteliais da Veia Umbilical Humana; Humanos; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Camundongos; Simulação de Acoplamento Molecular; Ligação Proteica; Domínios Proteicos; Quinazolinas/síntese química; Quinazolinas/metabolismo; Ratos; Ovinos; Tubulina (Proteína)/química; Tubulina (Proteína)/metabolismo; Moduladores de Tubulina/síntese química; Moduladores de Tubulina/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Anti-tumor; Anti-vascular; Colchicine domain; Microtubule; Tubulin inhibitor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinazolinas / Moduladores de Tubulina / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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