Histone acetyl transferase TIP60 inhibits the replication of influenza a virus by activation the TBK1-IRF3 pathway.

Ma, Guoyao; Chen, Lin; Luo, Jing; Wang, Bo; Wang, Chengmin; Li, Meng; Huang, Chengmei; Du, Juan; Ma, Jiajun; Chang, Yungfu; He, Hongxuan

Ma, Guoyao; Chen, Lin; Luo, Jing; Wang, Bo; Wang, Chengmin; Li, Meng; Huang, Chengmei; Du, Juan; Ma, Jiajun; Chang, Yungfu; He, Hongxuan.

Afiliação

Ma G; National Research Center for Wildlife Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, No.1-5 Beichenxilu, Chaoyang District, Beijing, 100101, People's Republic of China.
Chen L; University of the Chinese Academy of Sciences, Beijing, 100101, China.
Luo J; National Research Center for Wildlife Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, No.1-5 Beichenxilu, Chaoyang District, Beijing, 100101, People's Republic of China.
Wang B; University of the Chinese Academy of Sciences, Beijing, 100101, China.
Wang C; National Research Center for Wildlife Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, No.1-5 Beichenxilu, Chaoyang District, Beijing, 100101, People's Republic of China.
Li M; National Research Center for Wildlife Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, No.1-5 Beichenxilu, Chaoyang District, Beijing, 100101, People's Republic of China.
Huang C; University of the Chinese Academy of Sciences, Beijing, 100101, China.
Du J; National Research Center for Wildlife Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, No.1-5 Beichenxilu, Chaoyang District, Beijing, 100101, People's Republic of China.
Ma J; National Research Center for Wildlife Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, No.1-5 Beichenxilu, Chaoyang District, Beijing, 100101, People's Republic of China.
Chang Y; University of the Chinese Academy of Sciences, Beijing, 100101, China.
He H; National Research Center for Wildlife Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, No.1-5 Beichenxilu, Chaoyang District, Beijing, 100101, People's Republic of China.

Virol J ; 15(1): 172, 2018 11 08.

Article em En | MEDLINE | ID: mdl-30409205

Assuntos

Interações Hospedeiro-Patógeno; Vírus da Influenza A/fisiologia; Lisina Acetiltransferase 5/metabolismo; Proteínas de Ligação a RNA/metabolismo; Transdução de Sinais; Proteínas do Core Viral/metabolismo; Replicação Viral; Células A549; Replicação do DNA; Células HEK293; Humanos; Vírus da Influenza A/genética; Influenza Humana; Fator Regulador 3 de Interferon/genética; Fator Regulador 3 de Interferon/metabolismo; Lisina Acetiltransferase 5/genética; Proteínas do Nucleocapsídeo; Proteínas Serina-Treonina Quinases/genética; Proteínas Serina-Treonina Quinases/metabolismo; Proteínas de Ligação a RNA/genética; Regulação para Cima; Proteínas do Core Viral/genética

Palavras-chave

Histone acetyl transferase TIP60; Influenza a virus; Nucleoprotein; Polymerase activity; Type I interferon

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Replicação Viral / Transdução de Sinais / Proteínas do Core Viral / Proteínas de Ligação a RNA / Interações Hospedeiro-Patógeno / Lisina Acetiltransferase 5 Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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