Extracellular Vesicles from Wharton's Jelly Mesenchymal Stem Cells Suppress CD4 Expressing T Cells Through Transforming Growth Factor Beta and Adenosine Signaling in a Canine Model.

Crain, Sarah K; Robinson, Sally R; Thane, Kristen E; Davis, Airiel M; Meola, Dawn M; Barton, Bruce A; Yang, Vicky K; Hoffman, Andrew M

Crain, Sarah K; Robinson, Sally R; Thane, Kristen E; Davis, Airiel M; Meola, Dawn M; Barton, Bruce A; Yang, Vicky K; Hoffman, Andrew M.

Afiliação

Crain SK; 1 Regenerative Medicine Laboratory, Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts.
Robinson SR; 1 Regenerative Medicine Laboratory, Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts.
Thane KE; 1 Regenerative Medicine Laboratory, Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts.
Davis AM; 1 Regenerative Medicine Laboratory, Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts.
Meola DM; 1 Regenerative Medicine Laboratory, Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts.
Barton BA; 2 Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts.
Yang VK; 1 Regenerative Medicine Laboratory, Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts.
Hoffman AM; 1 Regenerative Medicine Laboratory, Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts.

Stem Cells Dev ; 28(3): 212-226, 2019 02 01.

Article em En | MEDLINE | ID: mdl-30412034

Assuntos

Adenosina/metabolismo; Linfócitos T CD4-Positivos/fisiologia; Proliferação de Células; Vesículas Extracelulares/metabolismo; Células-Tronco Mesenquimais/metabolismo; Fator de Crescimento Transformador beta/metabolismo; Animais; Linfócitos T CD4-Positivos/imunologia; Proteínas de Ligação ao Cálcio/metabolismo; Células Cultivadas; Proteínas de Ligação a DNA/metabolismo; Cães; Complexos Endossomais de Distribuição Requeridos para Transporte/metabolismo; Feminino; Transdução de Sinais; Fatores de Transcrição/metabolismo; Geleia de Wharton/citologia

Palavras-chave

MSC; Wharton's jelly; exosomes; extracellular vesicles; immune modulation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Adenosina / Fator de Crescimento Transformador beta / Proliferação de Células / Células-Tronco Mesenquimais / Vesículas Extracelulares Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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