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Insights into Streptococcus agalactiae PI-2b pilus biosynthesis and role in adherence to host cells.
Périchon, Bruno; Guignot, Julie; Szili, Noémi; Gao, Cherry; Poyart, Claire; Trieu-Cuot, Patrick; Dramsi, Shaynoor.
Afiliação
  • Périchon B; Institut Pasteur, Biology of Gram-positive Pathogens Unit, 75015, Paris, France; Centre National de la Recherche Scientifique (CNRS) ERL6002, France.
  • Guignot J; Institut Cochin, Equipe Barrières et Pathogènes, INSERM 1016, CNRS UMR 8104, 75014, Paris, France.
  • Szili N; Institut Pasteur, Biology of Gram-positive Pathogens Unit, 75015, Paris, France; Centre National de la Recherche Scientifique (CNRS) ERL6002, France.
  • Gao C; Institut Pasteur, Biology of Gram-positive Pathogens Unit, 75015, Paris, France; Centre National de la Recherche Scientifique (CNRS) ERL6002, France.
  • Poyart C; Institut Cochin, Equipe Barrières et Pathogènes, INSERM 1016, CNRS UMR 8104, 75014, Paris, France; Centre National de Référence des Streptocoques, Hôpitaux Universitaires Paris Centre, Assistance Publique-Hôpitaux de Paris, 75014, Paris, France.
  • Trieu-Cuot P; Institut Pasteur, Biology of Gram-positive Pathogens Unit, 75015, Paris, France; Centre National de la Recherche Scientifique (CNRS) ERL6002, France.
  • Dramsi S; Institut Pasteur, Biology of Gram-positive Pathogens Unit, 75015, Paris, France; Centre National de la Recherche Scientifique (CNRS) ERL6002, France. Electronic address: shaynoor.dramsi@pasteur.fr.
Microbes Infect ; 21(2): 99-103, 2019 03.
Article em En | MEDLINE | ID: mdl-30419351
ABSTRACT
The core PI-2b pilus present in "hypervirulent" ST-17 Streptococcus agalactiae strains consists of three pilin subunits (Spb1, Ap1 and Ap2) assembled by sortase SrtC1 and cell-wall anchored by Srt2. Spb1 was shown to be the major pilin and Ap2 the anchor pilin. Ap1 is a putative adhesin. Two additional genes, orf and lep, are part of this operon. The contribution of Lep and Ap1 to the biogenesis of the PI-2b pilus was investigated. Concerning the role of PI-2b, we found that higher PI-2b expression resulted in higher adherence to human brain endothelial cells and higher phagocytosis by human THP1 macrophages.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óperon / Infecções Estreptocócicas / Streptococcus agalactiae / Aderência Bacteriana / Fímbrias Bacterianas / Adesinas Bacterianas Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óperon / Infecções Estreptocócicas / Streptococcus agalactiae / Aderência Bacteriana / Fímbrias Bacterianas / Adesinas Bacterianas Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article