The Association of Maternal Age With Fetal Growth and Newborn Measures: The Mumbai Maternal Nutrition Project (MMNP).
Reprod Sci
; 26(7): 918-927, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-30419799
ABSTRACT
BACKGROUND:
Young maternal age is associated with poorer birth outcomes, but the mechanisms are incompletely understood. Using data from a prospective cohort of pregnant women living in Mumbai slums, India, we tested whether lower maternal age was associated with adverse fetal growth.METHODS:
Fetal crown-rump length (CRL) was recorded at a median (interquartile range, IQR) of 10 weeks' gestation (9-10 weeks). Head circumference (HC), biparietal diameter (BPD), femur length (FL), and abdominal circumference (AC) were recorded at 19 (19-20) and 29 (28-30) weeks. Newborns were measured at a median (IQR) of 2 days (1-3 days) from delivery. Gestation was assessed using prospectively collected menstrual period dates.RESULTS:
The sample comprised 1653 singleton fetuses without major congenital abnormalities, of whom 1360 had newborn measurements. Fetuses of younger mothers had smaller CRL (0.01 standard deviation [SD] per year of maternal age; 95% confidence interval CI 0.00-0.02 1 ; P = .04), and smaller HC, FL, and AC at subsequent visits. Fetal growth of HC (0.04 cm; 95% CI 0.02-0.05; P < .001), BPD (0.01 cm; 95% CI 0.00-0.01; P = .009), FL (0.04 cm; 95% CI 0.02-0.06; P < .001), and AC (0.01 cm; 95% CI 0.00-0.01; P = .003) up to the third trimester increased with maternal age. Skinfolds, head, and mid-upper arm circumferences were smaller in newborns of younger mothers. Adjusting for maternal prepregnancy socioeconomic status, body mass index, height, and parity attenuated the associations between maternal age and newborn size but did not change those with fetal biometry.CONCLUSION:
Fetuses of younger mothers were smaller from the first trimester onward and grew slower, independently of known confounding factors.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Desenvolvimento Infantil
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Estado Nutricional
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Idade Materna
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Fenômenos Fisiológicos da Nutrição Materna
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Desenvolvimento Fetal
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Retardo do Crescimento Fetal
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
/
Etiology_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
/
Female
/
Humans
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Male
/
Newborn
/
Pregnancy
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article