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Aging and drug discovery.
Bakula, Daniela; Aliper, Alexander M; Mamoshina, Polina; Petr, Michael A; Teklu, Amanuel; Baur, Joseph A; Campisi, Judith; Ewald, Collin Y; Georgievskaya, Anastasia; Gladyshev, Vadim N; Kovalchuk, Olga; Lamming, Dudley W; Luijsterburg, Martijn S; Martín-Montalvo, Alejandro; Maudsley, Stuart; Mkrtchyan, Garik V; Moskalev, Alexey; Olshansky, S Jay; Ozerov, Ivan V; Pickett, Alexander; Ristow, Michael; Zhavoronkov, Alex; Scheibye-Knudsen, Morten.
Afiliação
  • Bakula D; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Aliper AM; Pharmaceutical Artificial Intelligence Department, Insilico Medicine, Inc., Baltimore, MD 20850, USA.
  • Mamoshina P; Pharmaceutical Artificial Intelligence Department, Insilico Medicine, Inc., Baltimore, MD 20850, USA.
  • Petr MA; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Teklu A; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Baur JA; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Campisi J; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Ewald CY; Buck Institute for Research on Aging, Novato, CA 94945, USA.
  • Georgievskaya A; Lawrence Berkeley National Laboratory, Life Sciences Division, Berkeley, CA 94720, USA.
  • Gladyshev VN; Institute of Translational Medicine, Department of Health Sciences and Technology, Swiss Federal Institute for Technology (ETH) Zürich, Switzerland.
  • Kovalchuk O; Youth Laboratories, Moscow, Russia.
  • Lamming DW; Division of Genetics, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Luijsterburg MS; Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia.
  • Martín-Montalvo A; Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada.
  • Maudsley S; Pathway Rx Ltd, Lethbridge, Alberta, Canada.
  • Mkrtchyan GV; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.
  • Moskalev A; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
  • Olshansky SJ; Pancreatic Islet Development and Regeneration Unit/Laboratory of Aging Biology, Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.
  • Ozerov IV; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
  • Pickett A; Translational Neurobiology Group, Center of Molecular Neurology, VIB, Antwerp, Belgium.
  • Ristow M; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Zhavoronkov A; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
  • Scheibye-Knudsen M; Institute of Biology of Komi Science Center of Ural Branch of RAS, Syktyvkar, Russia.
Aging (Albany NY) ; 10(11): 3079-3088, 2018 11 13.
Article em En | MEDLINE | ID: mdl-30425188
ABSTRACT
Multiple interventions in the aging process have been discovered to extend the healthspan of model organisms. Both industry and academia are therefore exploring possible transformative molecules that target aging and age-associated diseases. In this overview, we summarize the presented talks and discussion points of the 5th Annual Aging and Drug Discovery Forum 2018 in Basel, Switzerland. Here academia and industry came together, to discuss the latest progress and issues in aging research. The meeting covered talks about the mechanistic cause of aging, how longevity signatures may be highly conserved, emerging biomarkers of aging, possible interventions in the aging process and the use of artificial intelligence for aging research and drug discovery. Importantly, a consensus is emerging both in industry and academia, that molecules able to intervene in the aging process may contain the potential to transform both societies and healthcare.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article