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Effects of lentivirus-mediated CYP17A1 gene silencing on the biological activity of glioma.
Niu, Wan-Xiang; Zhou, Chen-Xu; Cheng, Chuan-Dong; Bao, De-Jun; Dong, Yong-Fei; Li, Dong-Xue; Yang, Yang; He, Hu; Niu, Chao-Shi.
Afiliação
  • Niu WX; Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, China; Anhui Province Key Laboratory of Brain Function and Brain Disease, China; Anhui Provincial Stereotactic Neurosurgical Institute, China.
  • Zhou CX; Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, China; Anhui Province Key Laboratory of Brain Function and Brain Disease, China; Anhui Provincial Stereotactic Neurosurgical Institute, China.
  • Cheng CD; Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, China; Anhui Province Key Laboratory of Brain Function and Brain Disease, China; Anhui Provincial Stereotactic Neurosurgical Institute, China.
  • Bao DJ; Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, China; Anhui Province Key Laboratory of Brain Function and Brain Disease, China; Anhui Provincial Stereotactic Neurosurgical Institute, China.
  • Dong YF; Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, China; Anhui Province Key Laboratory of Brain Function and Brain Disease, China; Anhui Provincial Stereotactic Neurosurgical Institute, China.
  • Li DX; Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, China; Anhui Province Key Laboratory of Brain Function and Brain Disease, China; Anhui Provincial Stereotactic Neurosurgical Institute, China.
  • Yang Y; Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, China; Anhui Province Key Laboratory of Brain Function and Brain Disease, China; Anhui Provincial Stereotactic Neurosurgical Institute, China.
  • He H; Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, China; Anhui Province Key Laboratory of Brain Function and Brain Disease, China; Anhui Provincial Stereotactic Neurosurgical Institute, China.
  • Niu CS; Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, China; Anhui Province Key Laboratory of Brain Function and Brain Disease, China; Anhui Provincial Stereotactic Neurosurgical Institute, China. Ele
Neurosci Lett ; 692: 210-215, 2019 01 23.
Article em En | MEDLINE | ID: mdl-30439398
ABSTRACT
Gliomas are the most common malignant primary brain tumors with poor prognosis. We attempted to explore the role of CYP17A1 in glioma progression. We demonstrated that the expression of CYP17A1 was significantly higher in the glioma tissues than the normal brain tissues, especially in malignant glioma. Moreover, the expression of CYP17A1 gene was positively correlative with glioma pathological grades. In vitro, CYP17A1 gene silence inhibited the proliferation and invasion of glioma cells and promoted the apoptosis in glioma cells. Also, the subcutaneously transplanted tumour in BALB/C-nu showed that CYP17A1 gene silence inhibited glioma growth. These results reveal that CYP17A1 plays a major role in the progress of glioma.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Esteroide 17-alfa-Hidroxilase / Glioma Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Esteroide 17-alfa-Hidroxilase / Glioma Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article