Genetic deletion of vesicular glutamate transporter in dopamine neurons increases vulnerability to MPTP-induced neurotoxicity in mice.

Shen, Hui; Marino, Rosa Anna M; McDevitt, Ross A; Bi, Guo-Hua; Chen, Kai; Madeo, Graziella; Lee, Pin-Tse; Liang, Ying; De Biase, Lindsay M; Su, Tsung-Ping; Xi, Zheng-Xiong; Bonci, Antonello

Shen, Hui; Marino, Rosa Anna M; McDevitt, Ross A; Bi, Guo-Hua; Chen, Kai; Madeo, Graziella; Lee, Pin-Tse; Liang, Ying; De Biase, Lindsay M; Su, Tsung-Ping; Xi, Zheng-Xiong; Bonci, Antonello.

Afiliação

Shen H; Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224.
Marino RAM; Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224.
McDevitt RA; Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224.
Bi GH; Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224.
Chen K; Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224.
Madeo G; Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224.
Lee PT; Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224.
Liang Y; Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224.
De Biase LM; Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224.
Su TP; Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224.
Xi ZX; Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224.
Bonci A; Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224; antonello.bonci@nih.gov.

Proc Natl Acad Sci U S A ; 115(49): E11532-E11541, 2018 12 04.

Article em En | MEDLINE | ID: mdl-30442663

Assuntos

Neurônios Dopaminérgicos/fisiologia; Proteína Vesicular 2 de Transporte de Glutamato/metabolismo; Animais; Fator Neurotrófico Derivado do Encéfalo/genética; Fator Neurotrófico Derivado do Encéfalo/metabolismo; Fenômenos Eletrofisiológicos; Regulação da Expressão Gênica; Ácido Glutâmico/metabolismo; Intoxicação por MPTP; Masculino; Glicoproteínas de Membrana/genética; Glicoproteínas de Membrana/metabolismo; Camundongos; Atividade Motora/efeitos dos fármacos; Atividade Motora/genética; Mutação; Proteínas Tirosina Quinases/genética; Proteínas Tirosina Quinases/metabolismo; Proteína Vesicular 2 de Transporte de Glutamato/genética

Palavras-chave

BDNF; MPTP; Parkinson's disease; VgluT2; midbrain DA neurons

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Vesicular 2 de Transporte de Glutamato / Neurônios Dopaminérgicos Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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