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Three new labdane-type diterpenoids from Callicarpa macrophylla Vahl.
Wang, Zhen-Hui; Xu, Huan-Jun; Zhai, Yang-Yang; Yang, Lan-Ping; Li, Qiang; Huang, Mei; Chen, Xing-Ying; Zhang, Wen-Kui; Meng, Yue-Li; Zhang, Qing-Ling; Niu, Chao; Zhang, Yan-Ru.
Afiliação
  • Wang ZH; a College of Medicine, Henan Polytechnic University , Jiaozuo , P. R. China.
  • Xu HJ; b Hainan Bikai pharmaceutical Co., Ltd.
  • Zhai YY; a College of Medicine, Henan Polytechnic University , Jiaozuo , P. R. China.
  • Yang LP; a College of Medicine, Henan Polytechnic University , Jiaozuo , P. R. China.
  • Li Q; a College of Medicine, Henan Polytechnic University , Jiaozuo , P. R. China.
  • Huang M; a College of Medicine, Henan Polytechnic University , Jiaozuo , P. R. China.
  • Chen XY; a College of Medicine, Henan Polytechnic University , Jiaozuo , P. R. China.
  • Zhang WK; a College of Medicine, Henan Polytechnic University , Jiaozuo , P. R. China.
  • Meng YL; a College of Medicine, Henan Polytechnic University , Jiaozuo , P. R. China.
  • Zhang QL; a College of Medicine, Henan Polytechnic University , Jiaozuo , P. R. China.
  • Niu C; a College of Medicine, Henan Polytechnic University , Jiaozuo , P. R. China.
  • Zhang YR; a College of Medicine, Henan Polytechnic University , Jiaozuo , P. R. China.
Nat Prod Res ; 33(20): 2904-2910, 2019 Oct.
Article em En | MEDLINE | ID: mdl-30445877
ABSTRACT
Three new labdane-type diterpenoids, callicapene M3-M5 (1-3) were isolated from the Callicarpa macrophylla Vahl. Their structures were identified by spectroscopic method. The isolated compounds were evaluated for inhibitory activity on NO production in LPS-activated RAW 264.7 macrophage cells by using MTT assays. Compounds 1-3 showed potent inhibitory activity, with IC50 value of 48.15, 46.31 and 38.72 µM respectively.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Callicarpa / Diterpenos / Óxido Nítrico Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Callicarpa / Diterpenos / Óxido Nítrico Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article