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Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.
Bajzikova, Martina; Kovarova, Jaromira; Coelho, Ana R; Boukalova, Stepana; Oh, Sehyun; Rohlenova, Katerina; Svec, David; Hubackova, Sona; Endaya, Berwini; Judasova, Kristyna; Bezawork-Geleta, Ayenachew; Kluckova, Katarina; Chatre, Laurent; Zobalova, Renata; Novakova, Anna; Vanova, Katerina; Ezrova, Zuzana; Maghzal, Ghassan J; Magalhaes Novais, Silvia; Olsinova, Marie; Krobova, Linda; An, Yong Jin; Davidova, Eliska; Nahacka, Zuzana; Sobol, Margarita; Cunha-Oliveira, Teresa; Sandoval-Acuña, Cristian; Strnad, Hynek; Zhang, Tongchuan; Huynh, Thanh; Serafim, Teresa L; Hozak, Pavel; Sardao, Vilma A; Koopman, Werner J H; Ricchetti, Miria; Oliveira, Paulo J; Kolar, Frantisek; Kubista, Mikael; Truksa, Jaroslav; Dvorakova-Hortova, Katerina; Pacak, Karel; Gurlich, Robert; Stocker, Roland; Zhou, Yaoqi; Berridge, Michael V; Park, Sunghyouk; Dong, Lanfeng; Rohlena, Jakub; Neuzil, Jiri.
Afiliação
  • Bajzikova M; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic; Faculty of Science, Charles University, 128 44 Prague, Czech Republic.
  • Kovarova J; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic. Electronic address: jaromira.kovarova@ibt.cas.cz.
  • Coelho AR; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, UC-Biotech, Biocant Park, 3060-197 Cantanhede, Portugal.
  • Boukalova S; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic.
  • Oh S; College of Pharmacy, Natural Product Research Institute, Seoul National University, Seoul 08826, Korea.
  • Rohlenova K; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic.
  • Svec D; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic.
  • Hubackova S; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic.
  • Endaya B; School of Medical Science, Griffith University, Southport, QLD 4222, Australia.
  • Judasova K; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic.
  • Bezawork-Geleta A; School of Medical Science, Griffith University, Southport, QLD 4222, Australia.
  • Kluckova K; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic.
  • Chatre L; Department of Developmental and Stem Cell Biology, Institut Pasteur, 75015 Paris, France; CNRS UMR 3738, Team Stability of Nuclear and Mitochondrial DNA, 75015 Paris, France.
  • Zobalova R; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic.
  • Novakova A; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic.
  • Vanova K; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic.
  • Ezrova Z; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic; Faculty of Science, Charles University, 128 44 Prague, Czech Republic.
  • Maghzal GJ; Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia; St Vincent's Clinical School, UNSW Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
  • Magalhaes Novais S; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic; Faculty of Science, Charles University, 128 44 Prague, Czech Republic.
  • Olsinova M; Faculty of Science, Charles University, 128 44 Prague, Czech Republic.
  • Krobova L; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic.
  • An YJ; College of Pharmacy, Natural Product Research Institute, Seoul National University, Seoul 08826, Korea.
  • Davidova E; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic; Faculty of Science, Charles University, 128 44 Prague, Czech Republic.
  • Nahacka Z; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic.
  • Sobol M; Institute of Molecular Genetics, Czech Academy of Sciences, 142 20 Prague, Czech Republic.
  • Cunha-Oliveira T; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, UC-Biotech, Biocant Park, 3060-197 Cantanhede, Portugal.
  • Sandoval-Acuña C; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic.
  • Strnad H; Institute of Molecular Genetics, Czech Academy of Sciences, 142 20 Prague, Czech Republic.
  • Zhang T; Institute for Glycomics, Griffith University, Southport, 4222 QLD, Australia.
  • Huynh T; Eunice Kennedy Shriver Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
  • Serafim TL; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, UC-Biotech, Biocant Park, 3060-197 Cantanhede, Portugal.
  • Hozak P; Institute of Molecular Genetics, Czech Academy of Sciences, 142 20 Prague, Czech Republic.
  • Sardao VA; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, UC-Biotech, Biocant Park, 3060-197 Cantanhede, Portugal.
  • Koopman WJH; Department of Biochemistry (286), Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, 6525 Nijmegen, the Netherlands.
  • Ricchetti M; Department of Developmental and Stem Cell Biology, Institut Pasteur, 75015 Paris, France; CNRS UMR 3738, Team Stability of Nuclear and Mitochondrial DNA, 75015 Paris, France.
  • Oliveira PJ; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, UC-Biotech, Biocant Park, 3060-197 Cantanhede, Portugal.
  • Kolar F; Institute of Physiology, Czech Academy of Sciences, 142 20 Prague, Czech Republic.
  • Kubista M; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic.
  • Truksa J; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic.
  • Dvorakova-Hortova K; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic; Faculty of Science, Charles University, 128 44 Prague, Czech Republic.
  • Pacak K; Eunice Kennedy Shriver Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
  • Gurlich R; Third Faculty Hospital, Charles University, Prague, Czech Republic.
  • Stocker R; Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia; St Vincent's Clinical School, UNSW Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
  • Zhou Y; Institute for Glycomics, Griffith University, Southport, 4222 QLD, Australia.
  • Berridge MV; Malaghan Institute of Medical Research, Wellington 6242, New Zealand.
  • Park S; College of Pharmacy, Natural Product Research Institute, Seoul National University, Seoul 08826, Korea. Electronic address: psh@snu.ac.kr.
  • Dong L; School of Medical Science, Griffith University, Southport, QLD 4222, Australia. Electronic address: l.dong@griffith.edu.au.
  • Rohlena J; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic. Electronic address: rohlenaj@ibt.cas.cz.
  • Neuzil J; Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic; School of Medical Science, Griffith University, Southport, QLD 4222, Australia. Electronic address: j.neuzil@griffith.edu.au.
Cell Metab ; 29(2): 399-416.e10, 2019 02 05.
Article em En | MEDLINE | ID: mdl-30449682
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / DNA Mitocondrial / Oxirredutases atuantes sobre Doadores de Grupo CH-CH / Mitocôndrias / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / DNA Mitocondrial / Oxirredutases atuantes sobre Doadores de Grupo CH-CH / Mitocôndrias / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article