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Self-injurious behaviours in rhesus macaques: Potential glial mechanisms.
Ramsey, J; Martin, E C; Purcell, O M; Lee, K M; MacLean, A G.
Afiliação
  • Ramsey J; Tulane Brain Institute, Tulane University, New Orleans, LA.
  • Martin EC; Center for Stem Cell Research and Regenerative Medicine, School of Medicine, Tulane University, New Orleans, LA.
  • Purcell OM; Tulane Brain Institute, Tulane University, New Orleans, LA.
  • Lee KM; Tulane National Primate Research Center, Covington, LA.
  • MacLean AG; Tulane Program in Biomedical Science, Tulane Medical School, New Orleans, LA.
J Intellect Disabil Res ; 62(12): 1008-1017, 2018 12.
Article em En | MEDLINE | ID: mdl-30450801
BACKGROUND: Self-injurious behaviour (SIB) can be classified as intentional, direct injuring of body tissue usually without suicidal intent. In its non-suicidal form it is commonly seen as a clinical sign of borderline personality disorder, autism, PTSD, depression, and anxiety affecting a wide range of ages and conditions. In rhesus macaques SIB is most commonly manifested through hair plucking, self-biting, self-hitting, and head banging. SIB in the form of self-biting is observed in approximately 5-15% of individually housed monkeys. Recently, glial cells are becoming recognised as key players in regulating behaviours. METHOD: The goal of this study was to determine the role of glial activation, including astrocytes, in macaques that had displayed SIB. To this end, we performed immunohistochemistry and next generation sequence of brain tissues from rhesus macaques with SIB. RESULTS: Our studies showed increased vimentin, but not nestin, expression on astrocytes of macaques displaying SIB. Initial RNA Seq analyses indicate activation of pathways involved in tissue remodelling, neuroinflammation and cAMP signalling. CONCLUSIONS: Glia are most probably activated in primates with self-injury, and are therefore potential novel targets for therapeutics.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Neuroglia / Comportamento Autodestrutivo Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Neuroglia / Comportamento Autodestrutivo Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article