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Radiation-induced dermatitis after administration of mogamulizumab for adult T-cell leukaemia/lymphoma: a multi-institutional retrospective study.
Maemoto, Hitoshi; Ariga, Takuro; Kusada, Takeaki; Heianna, Joichi; Manabe, Yoshihiko; Miyakawa, Akifumi; Nakachi, Sawako; Morishima, Satoko; Iraha, Shiro; Ganaha, Fumikiyo; Masuzaki, Hiroaki; Murayama, Sadayuki.
Afiliação
  • Maemoto H; Department of Radiology, Okinawa Prefectural Nanbu Medical Center & Children's Medical Center, Okinawa, Japan.
  • Ariga T; Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Nishihara, Japan.
  • Kusada T; Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Nishihara, Japan.
  • Heianna J; Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Nishihara, Japan.
  • Manabe Y; Department of Radiology, Nanbu Tokushukai Hospital, Okinawa, Japan.
  • Miyakawa A; Department of Radiology, Nanbu Tokushukai Hospital, Okinawa, Japan.
  • Nakachi S; Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.
  • Morishima S; Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.
  • Iraha S; Department of Radiology, Okinawa Prefectural Nanbu Medical Center & Children's Medical Center, Okinawa, Japan.
  • Ganaha F; Department of Radiology, Okinawa Prefectural Nanbu Medical Center & Children's Medical Center, Okinawa, Japan.
  • Masuzaki H; Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.
  • Murayama S; Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Nishihara, Japan.
Jpn J Clin Oncol ; 49(2): 153-159, 2019 Feb 01.
Article em En | MEDLINE | ID: mdl-30452692
BACKGROUND: Cutaneous adverse reactions are frequently induced by mogamulizumab. Cases of Stevens-Johnson syndrome, toxic epidermal necrolysis and severe photosensitivity related to mogamulizumab have been reported. This study investigated whether severe radiation-induced dermatitis occurred in patients undergoing radiotherapy after the administration of mogamulizumab for adult T-cell leukaemia/lymphoma. METHODS: We retrospectively reviewed 46 courses of radiotherapy administered to 15 consecutive patients with adult T-cell leukaemia/lymphoma (acute, n = 7; lymphoma, n = 7; smouldering, n = 1) who received mogamulizumab before or during radiotherapy at three institutions between 2012 and 2017. RESULTS: During 43 of the 46 radiotherapy courses, patients developed Grade ≤1 radiation-induced dermatitis. No patient developed Grade ≥3 radiation-induced dermatitis. No patient was prescribed ointments as prophylactic treatment for radiation-induced dermatitis. Development of radiation-induced dermatitis was not significantly associated with the number of days since the administration of mogamulizumab prior to radiotherapy (P = 0.85), frequency of administration of mogamulizumab before/during radiotherapy (P = 0.33), administration of mogamulizumab during radiotherapy (P = 0.41) or types of lesions in adult T-cell leukaemia/lymphoma cases (cutaneous vs. non-cutaneous, P = 0.74). Development of radiation-induced dermatitis was significantly related to the total cutaneous dose (mean, 31.9 Gy [95% confidence interval: 26.6-37.1 Gy] vs. 19.7 Gy [95% confidence interval: 16.2-23.2 Gy], P = 0.0004) and total prescribed dose (mean, 31.5 Gy [95% confidence interval: 26.2-36.8 Gy] vs. 18.5 Gy [95% confidence interval: 15.0-22.0 Gy], P = 0.0002). CONCLUSION: None of the 15 patients who received moderate-dose radiotherapy developed severe radiation-induced dermatitis during the 46 courses of radiotherapy after mogamulizumab administration.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radiodermite / Leucemia-Linfoma de Células T do Adulto / Anticorpos Monoclonais Humanizados Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radiodermite / Leucemia-Linfoma de Células T do Adulto / Anticorpos Monoclonais Humanizados Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article