Novel Mechanistic Roles for Ankyrin-G in Cardiac Remodeling and Heart Failure.
JACC Basic Transl Sci
; 3(5): 675-689, 2018 Oct.
Article
em En
| MEDLINE
| ID: mdl-30456339
ABSTRACT
Ankyrin polypeptides are intracellular proteins responsible for targeting cardiac membrane proteins. Here, the authors demonstrate that ankyrin-G plays an unexpected role in normal compensatory physiological remodeling in response to myocardial stress and aging; the authors implicate disruption of ankyrin-G in human heart failure. Mechanistically, the authors illustrate that ankyrin-G serves as a key nodal protein required for cardiac myofilament integration with the intercalated disc. Their data define novel in vivo mechanistic roles for ankyrin-G, implicate ankyrin-G as necessary for compensatory cardiac physiological remodeling under stress, and implicate disruption of ankyrin-G in the development and progression of human heart failure.
AnkG, ankyrin-G; DSP, desmoplakin; ECG, electrocardiogram; HF, heart failure; LV, left ventricular; Nav1.5; PBS, phosphate-buffered saline; PKP2, plakophilin-2; TAC, transverse aortic constriction; TUNEL, terminal deoxynucleotidyl transferase dUTP nick-end labeling; WT, wild-type; ankyrin; arrhythmia; cKO, cardiomyocyte-specific knockout; cytoskeleton; heart failure; ion channel
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article