Cluster analysis of autoimmune rheumatic diseases based on autoantibodies. New insights for polyautoimmunity.
J Autoimmun
; 98: 24-32, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30459097
ABSTRACT
Autoimmune diseases (ADs) are a chronic and clinically heterogeneous group of diseases characterized by share common immunopathogenic mechanisms and risk factors (i.e., the autoimmune tautology), which explain the fact that one AD may coexist with others (i.e., polyautoimmunity - PolyA). In the present exploratory study, a mixed-cluster analysis of the most common autoimmune rheumatic diseases (ARDs) was done. A total of 187 consecutive women with established systemic lupus erythematosus (nâ¯=â¯70), rheumatoid arthritis (nâ¯=â¯51), systemic sclerosis (nâ¯=â¯35) and Sjögren's syndrome (nâ¯=â¯31) were included. A comprehensive clinical, autoantibody and cytokine assessment was simultaneously done. Total PolyA was registered in 142 (75.9%) patients. Six clusters were obtained, built mainly on autoantibodies PolyA-I to -VI. The PolyA-III cluster showed the highest frequency of overt PolyA (pâ¯=â¯0.01), and the PolyA-I, -III, and -IV clusters exhibited the highest positivity for IL-12/23p40 (pâ¯=â¯0.015). These results provide new insights into the pathophysiology of PolyA and warrant prospective validation to enable development of a more accurate taxonomy of ARDs.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
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Escleroderma Sistêmico
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Síndrome de Sjogren
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Interleucina-12
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Lúpus Eritematoso Sistêmico
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article