Site-Specific Integration by Recruitment of a Complex of &#934;C31 Integrase and Donor DNA to a Target Site by Using a Tandem, Artificial Zinc-Finger Protein.

Sumikawa, Tatsuhiko; Ohno, Serika; Watanabe, Takeharu; Yamamoto, Ryo; Yamano, Miyu; Mori, Tomoaki; Mori, Koichi; Tobimatsu, Takamasa; Sera, Takashi

Site-Specific Integration by Recruitment of a Complex of ΦC31 Integrase and Donor DNA to a Target Site by Using a Tandem, Artificial Zinc-Finger Protein.

Sumikawa, Tatsuhiko; Ohno, Serika; Watanabe, Takeharu; Yamamoto, Ryo; Yamano, Miyu; Mori, Tomoaki; Mori, Koichi; Tobimatsu, Takamasa; Sera, Takashi.

Afiliação

Sumikawa T; Department of Applied Chemistry and Biotechnology, Graduate School of Natural Science and Technology , Okayama University , Tsushima-Naka, Kita-ku , Okayama 700-8530 , Japan.
Ohno S; Department of Applied Chemistry and Biotechnology, Graduate School of Natural Science and Technology , Okayama University , Tsushima-Naka, Kita-ku , Okayama 700-8530 , Japan.
Watanabe T; Department of Applied Chemistry and Biotechnology, Graduate School of Natural Science and Technology , Okayama University , Tsushima-Naka, Kita-ku , Okayama 700-8530 , Japan.
Yamamoto R; Department of Applied Chemistry and Biotechnology, Graduate School of Natural Science and Technology , Okayama University , Tsushima-Naka, Kita-ku , Okayama 700-8530 , Japan.
Yamano M; Department of Applied Chemistry and Biotechnology, Graduate School of Natural Science and Technology , Okayama University , Tsushima-Naka, Kita-ku , Okayama 700-8530 , Japan.
Mori T; Department of Applied Chemistry and Biotechnology, Graduate School of Natural Science and Technology , Okayama University , Tsushima-Naka, Kita-ku , Okayama 700-8530 , Japan.
Mori K; Department of Applied Chemistry and Biotechnology, Graduate School of Natural Science and Technology , Okayama University , Tsushima-Naka, Kita-ku , Okayama 700-8530 , Japan.
Tobimatsu T; Department of Applied Chemistry and Biotechnology, Graduate School of Natural Science and Technology , Okayama University , Tsushima-Naka, Kita-ku , Okayama 700-8530 , Japan.
Sera T; Department of Applied Chemistry and Biotechnology, Graduate School of Natural Science and Technology , Okayama University , Tsushima-Naka, Kita-ku , Okayama 700-8530 , Japan.

Biochemistry ; 57(50): 6868-6877, 2018 12 18.

Article em En | MEDLINE | ID: mdl-30462489

Assuntos

DNA/genética; DNA/metabolismo; Integrases/genética; Integrases/metabolismo; Dedos de Zinco/genética; Sequência de Bases; Sítios de Ligação/genética; Proteínas de Ligação a DNA/química; Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Edição de Genes/métodos; Terapia Genética/métodos; Vetores Genéticos; Genoma Humano; Humanos; Integrases/química; Plasmídeos/genética; Engenharia de Proteínas; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Especificidade por Substrato; Temperatura

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / Dedos de Zinco / Integrases Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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