Linking hyperelastic theoretical models and experimental data of vaginal tissue through histological data.
J Biomech
; 82: 271-279, 2019 01 03.
Article
em En
| MEDLINE
| ID: mdl-30466952
ABSTRACT
Mechanical characterization of living tissues and computer-based simulations related to medical issues, has become increasingly important to improve diagnostic processes and treatments evaluation. This work proposes a link between the mechanical testing and the material model predictions through histological data of vaginal tissue. Histological data was used to link tensile testing experiments with material-dependent parameters; the approach was adequate to capture the nonlinear response of ovine vaginal tissue over a large strain range. The experimental data obtained on a previous study, has two main components tensile testing and histological analysis of the ovine vaginal tissue. Uniaxial tensile test data and histological data were collected from three sheep groups virgins, pregnant and parous. The distal part of vaginal wall was selected since it is prone to tears induced by vaginal delivery. The HGO (Holzapfel-Gasser-Ogden) model parameters were fitted using a stochastic approach, namely the Simple Genetic Algorithm (SGA). The SGA was able to fit the experimental data successfully (R2â¯>â¯0.986). The dimensionless coefficient ξ, was highly correlated with histological data. The ratio was seen to increase linearly with increasing collagen content. Coefficient ξ brings a new way of interpreting and understanding experimental data; it connects the nonlinear mechanical behaviour (tensile test) with tissue's morphology (histology). It can be used as an 'inverse' (approximate) method to estimate the mechanical properties without direct experimental measurements, through basic histology. In this context, the proposed methodology appears very promising in estimating the response of the tissue via histological information.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vagina
/
Elasticidade
/
Modelos Biológicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Female
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Humans
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Pregnancy
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article